非小细胞肺癌骨转移患者血清S100A4的表达水平及其诊断价值  

Expression of serum S100A4 in non-small cell lung cancer patients with bone metastasis and its diagnostic value

作　　者：李多 郝昭昭 陈延伟 南岩东 Li Duo;Hao Zhaozhao;Chen Yanwei;Nan Yandong(Department of Respiratory and Critical Care Medicine,Tangdu Hospital,Air Force Medical University,Xi′an 710038,China)

机构地区：[1]空军军医大学唐都医院呼吸与危重症医学科,西安710038

出　　处：《国际呼吸杂志》2024年第5期558-562,共5页International Journal of Respiration

摘　　要：目的探讨非小细胞肺癌(NSCLC)骨转移患者血清S100A4的表达水平及其诊断价值。方法本研究为横断面研究,采用目的抽样法选取2022年9月至2023年7月在空军军医大学唐都医院就诊的187例转移性NSCLC患者,根据有无骨转移分为NSCLC骨转移组(68例)与NSCLC非骨转移组(119例)。同时选取同期健康体检者50名作为健康对照组。采用酶联免疫吸附试验检测各组血清S100A4表达水平。收集NSCLC骨转移组患者临床资料,包括癌症家族史、吸烟指数、身体质量指数、病理类型、原发灶位置、单器官转移、骨转移类型、骨转移灶数量、高钙血症、高碱性磷酸酶血症。比较3组的性别、年龄和血清S100A4表达水平。分析NSCLC骨转移患者血清S100A4表达与临床特征的关系。采用简单随机抽样法选取NSCLC骨转移组25例患者,比较治疗前后血清S100A4表达变化。采用受试者操作特征(ROC)曲线评估血清S100A4对NSCLC患者骨转移的诊断效能。结果NSCLC骨转移组中男41例,女27例;年龄(59.82±10.89)岁。NSCLC非骨转移组中男81例,女38例;年龄(60.81±8.87)岁。健康对照组中男30名,女20名;年龄(58.84±9.68)岁。3组性别、年龄分布比较,差异均无统计学意义(均P>0.05)。3组血清S100A4表达水平比较差异有统计学意义(H=118.62,P<0.001)。NSCLC骨转移组、NSCLC非骨转移组血清S100A4含量均较健康对照组升高[374.84(614.77)ng/L、98.02(81.77)ng/L比40.47(21.67)ng/L],NSCLC骨转移组血清S100A4含量高于NSCLC非骨转移组,差异均有统计学意义(均P<0.05)。高碱性磷酸酶血症的NSCLC骨转移患者较血碱性磷酸酶含量正常的NSCLC骨转移患者血清S100A4表达水平高(Z=2.22,P=0.027);其他临床特征比较差异均无统计学意义(均P>0.05)。25例NSCLC骨转移组患者治疗后血清S100A4水平较治疗前下降[118.74(195.54)ng/L比332.26(586.92)ng/L,Z=2.71,P=0.007]。ROC曲线分析结果显示,血清S100A4诊断NSCLC骨转移患者的�Objective To detect the expression of serum S100A4 in bone metastasis of non-small cell lung cancer(NSCLC)and to investigate its diagnostic value.Methods This was a cross-sectional study.A total of 187 metastatic NSCLC patients treated in Tangdu Hospital of Air Force Medical University from September 2022 to July 2023 were selected by purposive sampling method.According to the presence or absence of bone metastasis,they were assigned into NSCLC bone metastasis group(n=68)and NSCLC non-bone metastasis group(n=119).At the same time,50 healthy people were selected as the healthy control group.Enzyme-linked immunosorbent assay was used to detect the serum level of S100A4 in each group.The clinical information of NSCLC patients with bone metastases were collected,including family history of cancer,smoking index,body mass index(BMI),pathological type,primary tumor location,single organ metastasis,type of bone metastases,number of bone metastases,hypercalcemia,and hyperalkaline phosphatase.The gender,age and serum S100A4 level of the three groups were compared.The correlation between serum S100A4 level and clinicopathological features of NSCLC patients with bone metastasis was analyzed.Serum S100A4 levels before and after treatment were compared in 25 NSCLC patients with bone metastasis who were selected by simple random sampling method.Receiver operating characteristic(ROC)curves were plotted to evaluate the diagnostic efficacy of serum S100A4 on bone metastasis of NSCLC.Results There were 41 males and 27 females in the NSCLC bone metastasis group with the mean age of 59.82±10.89 years.There were 81 males and 38 females in the NSCLC non-bone metastasis group,with the mean age of 60.81±8.87 years.There were 30 males and 20 females in the healthy control group,with the mean age of 58.84±9.68 years.There were no significant differences in the distributions of gender and age among the three groups(both P>0.05).There was a significant difference in serum S100A4 level among the three groups(H=118.62,P<0.001).Serum S100A4

关 键 词：癌 非小细胞肺 血清 S100A4 骨转移 

分 类 号：R734.2[医药卫生—肿瘤]