环状RNA与认知功能障碍相关疾病  

circular RNA and cognitive dysfunction related diseases

作　　者：刘树齐 邬鑫雨 林佳槟 殷盛明[1] Liu Shuqi;Wu Xinyu;Lin Jiabin;Yin Shengming(College of Basic Medical Sciences of Dalian Medical University,Dalian 116044,China;The Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China)

机构地区：[1]大连医科大学基础医学院,大连116044 [2]大连医科大学附属第二医院,大连116027

出　　处：《中华行为医学与脑科学杂志》2024年第5期470-474,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：大连医科大学大学生创新创业训练计划项目(X202210161102,X202210161094)。

摘　　要：环状RNA(circular RNA,circRNA)广泛存在于真核生物中。在具有认知功能下降的动物模型和认知功能障碍的人群中,均发现特定circRNA表达异常,但其在认知功能障碍相关疾病中的作用尚不清楚。本综述重点介绍circRNA在认知功能相关脑区的表达、circRNA对脑结构和功能的影响、circRNA参与认知功能障碍相关疾病的病理发生机制的相关研究进展,以期为揭示circRNA在认知功能障碍相关疾病中的病理作用机制,发现防治认知功能障碍的特定circRNA靶点提供理论依据。Circular RNA(circRNA)is widely expressed in eukaryotes.Abnormal expression of specific circRNA was found in both animal models with cognitive decline and patients with cognitive dysfunction.However,the role of circRNA in cognitive dysfunction related diseases is still unclear.By introducing the expression of circRNA in cognitive function related brain regions and its impact on brain structure and function,as well as the relevant research progress on the pathological mechanism of circRNA involvement in cognitive dysfunction related diseases,this review provides theoretical basis for revealing the pathological mechanism of circRNA in cognitive dysfunction related diseases and discovering specific circRNA targets for preventing and treating cognitive dysfunction.

关 键 词：环状RNA 微小RNA 认知功能 认知功能障碍 分子生物标志物 

分 类 号：R749[医药卫生—神经病学与精神病学]