GM-CSF Promotes the Development of Dysfunctional Vascular Networks in Moyamoya Disease  

作　　者：Huiqin Li Xiang Cao Xinya Gu Mengqi Dong Lili Huang Chenglu Mao Shengnan Xia Haiyan Yang Xinyu Bao Yongbo Yang Yun Xu 

机构地区：[1]Department of Neurology and Neurosurgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,210008,China [2]Department of Neurology and Neurosurgery,Nanjing Drum Tower Hospital,State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases,Nanjing University,Nanjing,210008,China [3]Department of Neurology and Neurosurgery,Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University,Nanjing,210008,China [4]Department of Neurology and Neurosurgery,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing,210008,China [5]Jiangsu Key Laboratory for Molecular Medicine,Medical School of Nanjing University,Nanjing,210008,China [6]Jiangsu Provincial Key Discipline of Neurology,Nanjing,210008,China [7]Nanjing Neurology Medical Center,Nanjing,210008,China

出　　处：《Neuroscience Bulletin》2024年第4期451-465,共15页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(82271334,82130036,81920108017,82171310);the National Science and Technology Innovation 2030--Major Program of"Brain Science and Brain-Like Research"(2022ZD0211800);Jiangsu Provincial‘333’High-level Talent Training Project Funding,the Key Research and Development Program of Jiangsu Province of China(BE2020620);Jiangsu Province Key Medical Discipline(ZDXK202216).

摘　　要：Moyamoya disease(MMD)is a chronic occlusive cerebrovascular disease with the development of a network of abnormal vessels.Immune inflammation is associated with the occurrence and development of MMD.However,the mechanisms underlying the formation of the abnormal vascular network remain unclear.Twenty-eight patients with MMD,26 ischemic stroke patients,and 26 unrelated healthy volunteers were enrolled in this study The data showed that the levels of granulocyte-macrophage colony-stimulating factor(GM-CSF)were higher in MMD patients than in healthy controls(P<0.01),and GM-CSF was mainly from Th1 and Th17 cells in MMD.We found that increased GM-CSF drove monocytes to secrete a series of cytokines associated with angiogenesis,inflammation,and chemotaxis.In summary,our findings demonstrate for the first time the important involvement of GM-CSF in MMD and that GM-CSF is an important factor in the formation of abnormal vascular networks in MMD.

关 键 词：Moyamoya disease Vascular endothelial cells GM-CSF VEGF 

分 类 号：R749.16[医药卫生—神经病学与精神病学]