Relationship Between Short-chain Fatty Acids and Parkinson’s Disease:A Review from Pathology to Clinic  

作　　者：Wen-Xiang Duan Fen Wang Jun-Yi Liu Chun-Feng Liu 

机构地区：[1]Department of Neurology and Clinical Research Center of Neurological Disease,The Second Affiliated Hospital of Soochow University,Suzhou,215004,China [2]Department of Neurology,Dushu Lake Hospital affiliated to Soochow University,Suzhou,215125,China [3]Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience,Soochow University,Suzhou,215123,China

出　　处：《Neuroscience Bulletin》2024年第4期500-516,共17页神经科学通报（英文版）

基　　金：supported by the Jiangsu Provincial Key R&D Program(BE2018658);Jiangsu Provincial Medical Key Discipline(ZDXK202217);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).

摘　　要：Parkinson’s disease(PD)is a complicated neurodegenerative disease,characterized by the accumulation ofα-synuclein(α-syn)in Lewy bodies and neurites,and massive loss of midbrain dopamine neurons.Increasing evidence suggests that gut microbiota and microbial metabolites are involved in the development of PD.Among these,short-chain fatty acids(SCFAs),the most abundant microbial metabolites,have been proven to play a key role in brain-gut communication.In this review,we analyze the role of SCFAs in the pathology of PD from multiple dimensions and summarize the alterations of SCFAs in PD patients as well as their correlation with motor and non-motor symptoms.Future research should focus on further elucidating the role of SCFAs in neuroinflammation,as well as developing novel strategies employing SCFAs and their derivatives to treat PD.

关 键 词：Parkinson’s disease Short-chain fatty acids Microbial metabolites Brain-gut-microbiota axis 

分 类 号：R742.5[医药卫生—神经病学与精神病学]