早发性结直肠癌的诊治进展  

Research progress of diagnosis and treatment of early-onset colorectal cancer

作　　者：李雅琪 李心翔[1] Li Yaqi;Li Xinxiang(Department of Colorectal Surgery,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属肿瘤医院大肠外二科、复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中华胃肠外科杂志》2024年第5期441-446,共6页Chinese Journal of Gastrointestinal Surgery

基　　金：国家自然科学基金(81972260,82372974);上海市教育委员会与上海市教育发展基金会“晨光计划”(20CG08)。

摘　　要：近年来,早发性结直肠癌(EOCRC)的发病率持续上升,但其发病机制尚不清楚。EOCRC的临床特征和分子病理学特征不同于晚发性结直肠癌,但目前两者治疗并无差别,尚缺乏关于EOCRC针对性的筛查及诊治指南。本文总结了EOCRC患者的流行病学特点、危险因素、临床特征、分子病理特征、发生发展机制及预防筛查策略的研究进展,以期为EOCRC的诊治提供理论依据。In recent years,the incidence rate of early-onset colorectal cancer(EOCRC)continues to rise,but its pathogenesis is still unclear.EOCRC is different from late-onset colorectal cancer in terms of the clinical and molecular pathological features,but their treatment strategies are the same,due to a lack of specific guidelines of screening,diagnosis and treatment for EOCRC.This article summarizes the research progress of epidemiological characteristics,risk factors,clinical features,molecular pathological features,pathogenesis,and prevention and screening strategies for EOCRC,in order to provide theoretical basis for the clinical treatment of patients with EOCRC.

关 键 词：结直肠肿瘤 早发性 流行病学 危险因素 临床特征 分子特征 

分 类 号：R735.34[医药卫生—肿瘤]