膳食对早发性结直肠癌发病的影响研究进展  

Research progress on the impact of diet on the early-onset colorectal cancer

作　　者：卢彬[1] 金天 刘成成 肖乾 代敏 Lu Bin;Jin Tian;Liu Chengcheng;Xiao Qian;Dai Min(Department of Nursing,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;Department of Colorectal Surgery and Oncology,Key Laboratory of Cancer Prevention and Intervention,Ministry of Education,the Second Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Cancer,Hangzhou 310009,China;Center for medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310058,China;Department of Epidemiology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]浙江大学医学院附属第二医院护理部,杭州310009 [2]浙江大学医学院附属第二医院大肠外科、恶性肿瘤预警与干预教育部重点实验室、浙江省恶性肿瘤临床医学研究中心,杭州310009 [3]消化系统医药基础研究创新中心(教育部),杭州310058 [4]国家癌症中心、肿瘤临床医学研究中心、中国医学科学院、北京协和医学院肿瘤医院流行病学研究室,北京100021

出　　处：《中华胃肠外科杂志》2024年第5期527-534,共8页Chinese Journal of Gastrointestinal Surgery

基　　金：浙江省自然科学基金(Q23H260015);浙江省重点研发计划项目“领雁”计划(2023C03049)。

摘　　要：近年来早发性结直肠癌的发病率呈现逐渐上升的趋势。研究表明,早发性结直肠癌与可改变的风险因素如膳食密切相关,但目前仍缺少一致性的结论,且缺乏对相关研究结果的系统阐述。本文全面总结了膳食与早发性结直肠癌的关联,明确不同膳食模式、常见食物种类及营养素与早发性结直肠癌发生之间的关联及其相对危险度,并阐述其潜在的生理学机制,加强对膳食这类可改变的外源性风险因素的认识,以期为早发性结直肠癌的一级预防策略制定提供参考。The incidence of early-onset colorectal cancer has been gradually increasing in recent years.Studies have shown that early-onset CRC is closely related to modifiable risk factors such as diet,but there is still a lack of consistent conclusions and a systematic review of relevant research results.In this review,we comprehensively summarized the association between diet and the early-onset CRC,clarified the association and relative risk between different dietary patterns,common food types and nutrients and the occurrence of early-onset CRC,and elaborated the underlying physiological mechanisms.Enhancing the understanding of dietary risk factors,which are modifiable exogenous risk factors,is expected to serve as a reference for the formulation of primary prevention strategies for early-onset CRC.

关 键 词：早发性 相对危险度 结直肠癌 食物种类 生理学机制 膳食模式 风险因素 一级预防策略 

分 类 号：R735.34[医药卫生—肿瘤]