Effect of the traditional Chinese medicine fumigation combined with the meibomian gland squeezer for treatment of dry eye associated with meibomian gland dysfunction  

作　　者：Da-Hu Wang Lin Mu Xiao-Yu Wu Yin-Jian Zhang Xin-Quan Liu 

机构地区：[1]Department of Ophthalmology,Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China [2]Department of Ophthalmology,Eye&ENT Hospital of Fudan University,Shanghai 200031,China

出　　处：《Integrative Medicine Discovery》2024年第15期1-5,共5页

基　　金：supported by the Young Talent Program of LongHua Hospital Shanghai University of Traditional Chinese Medicine(No.RC-2020-01-08);the Comprehensive Hospital Traditional Chinese and Western Medicine Guidance Project(No.ZXXT-202307).

摘　　要：Background:To observe the effect of traditional Chinese medicine fumigation combined with the meibomian gland squeezer for the treatment of dry eye associated with meibomian gland dysfunction(MGD).Methods:This is a randomized,controlled,non-masked,single-center study.Seventy-four cases(74 eyes)of dry eye associated with MGD were randomly divided into two groups.Thirty-seven patients were chosen as the treatment group was treated by the traditional Chinese medicine fumigation 3 times a week combined with the meibomian gland squeezer once a week for one month.The other 37 cases were sorted as the control group and only treated with the meibomian gland squeezer once a week for one month.Both groups received the primary treatment for 1 month,including Tobradex eye ointment once a day and 0.1%sodium hyaluronate eye drops 4-6 times daily.Patients were evaluated at baseline and 2-week and 1-month visits for the ocular symptom scores,international ocular surface disease index(OSDI),fluorescein tear break-up time(TBUT),corneal fluorescein staining test(CFS),Schirmer I test,meibum quality and meibum expressibility.Results:Sixty-seven patients were followed in the study,and the mean age was 57(±12.6)years.Thirty-three patients(11 males)in the treatment group and 34 patients(8 males)in the control group were followed in the study,and the mean age of the two groups was 45.36±15.02 years and 43.68±13.43 years,respectively.Before treatment,there was no significant difference between the two groups in gender,age,ocular symptom scores,OSDI,TBUT,CFS,Schirmer I test,meibum quality,and meibum expressibility(P>0.05).Compared with baseline,the 2 groups had different degrees of improvement in the ocular symptom scores,OSDI,TBUT,CFS,meibum quality,and meibum expressibility at the 2-week and 1-month visits(P<0.05),and the treatment group showed a more significant improvement in the ocular symptom scores,OSDI,TBUT,CFS,meibum quality and meibum expressibility compared with the control group(P<0.05).In addition,no serious adverse events

关 键 词：meibomian gland squeezer traditional Chinese medicine dry eye disease meibomian gland dysfunction 

分 类 号：R777.34[医药卫生—眼科] R777.13[医药卫生—临床医学]