Clinical Efficacy of Ultrasonic Medicinal Penetration in the Removal of Blood Stasis and Alleviation of Zhuyu Juanbi Formula in the Treatment of Peripheral Neuropathy Induced by Paclitaxel  

作　　者：Ying Zhang Huixin Chen Qirong Zhang Yingjie Jia Dan Yi 

机构地区：[1]The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China [2]National Clinical Research Center of Acupuncture and Moxibustion,Tianjin 300381,China [3]Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

出　　处：《Proceedings of Anticancer Research》2024年第3期7-17,共11页抗癌研究

摘　　要：Objective: To observe the clinical efficacy and differences of the Zhuyu Juanbi formula delivered through ultrasound at Zusanli on patients with chemotherapy-induced peripheral neuropathy (CIPN) due to paclitaxel injection. Methods: A total of 72 breast cancer patients with CIPN were randomly divided into two groups. The treatment group (36 cases) was treated with oral methylcobalamin plus ultrasonic medicine permeating Zhuyu Juanbi formulae, while the control group (36 cases) was treated with oral methylcobalamin alone. Following two 2 cycles of continuous treatment, the efficacy of peripheral neurotoxicity, TCM syndrome score, FACT/GOG-Ntx score, total neuropathy score, and safety indicators of gynecological cancer patients were observed in the two groups. Result: In the treatment of CIPN, the addition of ultrasonic medicine permeating Zhuyu Juanbi formulae was more effective than oral methylcobalamin alone in reducing peripheral neurotoxicity and improving the quality of life of patients. The difference between the two groups was statistically significant (P < 0.05), and ultrasound drug penetration Zhuyu Juanbi formulae significantly reduced the FACT/ GOG-Ntx score and TNS score in the treatment group. In terms of drug safety, it rarely caused adverse reactions such as grade 3 and 4 leukopenia, and the safety profile was therefore good. Conclusion: The combination of ultrasonic medicine permeating Zhuyu Juanbi formulae and methylcobalamin has been demonstrated to be an effective treatment for peripheral neurotoxicity in patients with PIPN. It has been shown to significantly improve the clinical symptoms of PIPN patients, improve the quality of life of patients, and have a good safety profile.

关 键 词：Chemotherapy-induced peripheral neuropathy(CIPN) Paclitaxel-induced peripheral neuropathy Zhuyu Juanbi formulae Ultrasonic drug delivery 

分 类 号：R73[医药卫生—肿瘤]