中国人人体血清中多氟和全氟烷基化合物及其与血清生化指标的关联性研究  

Research on Relationship between Traditional/emerging Per/polyfluoroalkyl Substances in Chinese Serum and Human Body Function Indicators

作　　者：李钰涛 黄语 唐冲 金航标 方淑红[1] Li Yutao;Huang Yu;Tang Chong;Jin Hangbiao;Fang Shuhong(College of Resources and Environment,Chengdu University of Information Technology,Chengdu 610225,China;College of Environment,Zhejiang University of Technology,Hangzhou 310023,China)

机构地区：[1]成都信息工程大学资源环境学院,成都610225 [2]浙江工业大学环境学院,杭州310023

出　　处：《生态毒理学报》2024年第3期36-48,共13页Asian Journal of Ecotoxicology

基　　金：国家自然科学基金项目(21607018);四川省科技计划项目(2021YJ0384);成都信息工程大学科技创新能力提升计划项目(KYQN202214)。

摘　　要：本研究对53名东部沿海居民血清中25种多氟/全氟化合物(PFASs)含量进行测定,分析PFASs浓度与肝肾功能指标碱性磷酸酶(ALP)、血清肌酐(SCR),抗RO52抗体等血清参数的关联性。血清中共检出14种PFASs,∑_(14)PFASs浓度范围为5.48~297 ng·mL^(-1),其中全氟辛烷羧酸(PFOA)与全氟辛烷磺酸(PFOS)为主要污染物,中位数分别为9.90 ng·mL^(-1)和7.45 ng·mL^(-1)。氯代多氟烷基醚磺酸(6:2 Cl-PFESA)是唯一检测到的新型多氟化合物,中位数为0.84 ng·mL^(-1)。全氟丁酸(PFBA)与ALP成正相关(r=0.588,P<0.05),说明PFBA浓度的增高可能会引起肝功能受损,PFOS与SCR呈负相关(r=-0.605,P<0.05),PFOS的暴露会对肾功能产生不良影响,全氟壬酸(PFNA)与抗RO52抗体滴度呈负相关性(r=-0.768,P<0.01),PFNA可能是自身免疫系统疾病的潜在致病因素。In this study,we quantified twenty-five types of poly-and perfluoroalkyl substances(PFASs)in the serum of 53 residents from eastern coastal areas in China to investigate the associations between PFAS exposure and v arious biomarkers of liver and kidney function.These biomarkers included alkaline phosphatase(ALP),serum c reatinine(SCR),and anti-RO52 antibody levels,among others.We detected 14 PFASs in the serum samples,with total concentrations(∑_(14)PFASs)ranging from 5.48 to 297 ng·mL^(-1).Perfluorooctanoic acid(PFOA)and p erfluorooctanesulfonic acid(PFOS)were the predominant contaminants,exhibiting median concentrations of 9.90 ng·mL^(-1)and 7.45 ng·mL^(-1),respectively.The only emerging polyfluorinated compound identified was chlorinated polyfluoroalkyl ether sulfonic acid(6:2 Cl-PFESA),with a median concentration of 0.84 ng·mL^(-1).Notably,p erfluorobutanoic acid(PFBA)showed a significant positive correlation with ALP(r=0.588,P<0.05),suggesting that increased PFBA levels may impair liver function.Conversely,PFOS was significantly negatively correlated with serum creatinine(r=-0.605,P<0.05),indicating its detrimental effects on renal function.Additionally,a s ignificant negative correlation was observed between perfluorononanoic acid(PFNA)and anti-RO52 antibody t iters(r=-0.768,P<0.01),highlighting PFNA as a potential risk factor for autoimmune diseases.

关 键 词：多/全氟化合物 血清 暴露特征 自身免疫毒性 

分 类 号：X171.5[环境科学与工程—环境科学]