氧化玉米淀粉/明胶复合胶囊壳的制备与表征  

Preparation and characterization of oxidized corn starch/gelatin composite capsules

作　　者：谭心 梁春艳 邓松林[2] 陈启杰[1] 罗永清 TAN Xin;LIANG Chunyan;DENG Songlin;CHEN Qijie;LUO Yongqing(School of Chemistry and Chemical Engineering,Changsha University of Science&Technology,Changsha,Hunan 410076,China;College of Mechanical Engineering,Hunan Industry Polytechnic,Changsha,Hunan 410000,China;Yueyang Tiantian Capsule Co.,Ltd.,Yueyang,Hunan 414000,China)

机构地区：[1]长沙理工大学化学化工学院,湖南长沙410076 [2]湖南工业职业技术学院机械工程学院,湖南长沙410000 [3]岳阳天添胶囊股份有限公司,湖南岳阳414000

出　　处：《食品与机械》2024年第5期188-193,共6页Food and Machinery

基　　金：国家级大学生创新训练计划项目(编号:S202310536039)。

摘　　要：目的:采用改性淀粉与明胶共混制备胶囊壳,降低胶囊壳制备成本。方法:以玉米原淀粉为原料,采用15%用量的过氧化氢氧化制备氧化玉米淀粉,与明胶共混,分别通过流延法和浸渍法制备了氧化玉米淀粉/明胶复合胶囊膜和胶囊壳,并采用傅里叶变换红外光谱(FT-IR)、X射线衍射(XRD)、扫描电子显微镜(SEM)对其进行表征。结果:当氧化玉米淀粉与明胶质量比为5∶5,制备的氧化玉米淀粉/明胶复合胶囊壳的干燥失重在13.0%~15.0%,在蒸馏水和模拟人工胃液中的崩解时限在10 min以内,脆碎度不超过5粒。结论:采用氧化玉米淀粉与明胶共混制备的复合胶囊壳性能符合《中国药典》(2020)要求。Objective:Modified starch was used to mix with gelatin to prepare the capsule shell,and the cost of preparing the capsule shell was reduced.Methods:Oxidized corn starch prepared by using 15%hydrogen peroxide was used as raw material to mix with part of gelatin.The oxidized corn starch/gelatin composite film and capsules were prepared by casting method and impregnation method,respectively,and were characterized by Fourier transform infrared spectroscopy(FT-IR),X-ray diffraction(XRD)and Scanning electron microscopy(SEM).Results:The results showed that the ratio of oxidized corn starch and gelatin was 5∶5,the drying weight loss of oxidized corn starch/gelatin composite capsules was 13.0%~15.0%,the disintegration time in distilled water and simulated artificial gastric juice was less than 10min,and the crunchability was not more than 5 granules.Conclusion:The properties of the composite capsule prepared by blending oxidized corn starch with gelatin met the requirements of Chinese Pharmacopoeia(2020).

关 键 词：氧化玉米淀粉 明胶 胶囊壳 制备 表征 

分 类 号：TQ460.4[化学工程—制药化工]