基于CiteSpace及VOSviewer的乳腺癌微环境研究热点可视化分析  

Visualization Analysis of Research Hotspots of Breast Cancer Microenvironment Based on CiteSpace and VOSviewer

作　　者：方宇航 谢伊 杨舒涵 刘苏颖 房立源 王妍 王润兮 张英[1] FANG Yuhang;XIE Yi;YANG Shuhan;LIU Suying;FANG Liyuan;WANG Yan;WANG Runxi;ZHANG Ying(Department of Oncology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Graduate School,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院广安门医院肿瘤科,北京100053 [2]北京中医药大学研究生院,北京100029

出　　处：《肿瘤防治研究》2024年第6期448-454,共7页Cancer Research on Prevention and Treatment

基　　金：国家中医药传承创新团队项目(ZYYCXTDC-202205);中国中医药循证医学中心业务研究室主任专项(2020YJSZX-3)。

摘　　要：目的基于知识图谱探析乳腺癌微环境的研究现状,并预测未来研究热点。方法检索中国知网及Web of Science Core Collection数据库近20年乳腺癌微环境相关文献,并运用CiteSpace、VOSviewer等软件进行文献计量学分析。结果共检索到中文文献825篇,英文文献16221篇。可视化分析显示科研人员的研究重点逐渐从细胞研究转向分子方向及药物创新层面,肿瘤干细胞、PD-1、PD-L1、免疫检查点抑制剂、纳米颗粒等是目前乳腺癌微环境研究的热点。美国乳腺癌微环境的相关研究最多,其次为中国、意大利。结论目前的研究热点主要集中在肿瘤细胞干性、免疫治疗、纳米递送等领域。随着对该领域研究的不断深入,通过靶向乳腺癌微环境预防肿瘤发展及转移,改善肿瘤预后成为新的研究趋势。Objective To explore the status of knowledge graph-based research into breast cancer microenvironment and to predict future research hotspots.Methods The literature related to breast cancer microenvironment in recent 20 years was retrieved from CNKI and Web of Science Core Collection database and analyzed with CiteSpace and VOSviewer.Results A total of 825 Chinese articles and 16,221 English articles were retrieved.Visual analysis showed that research focus has gradually shifted from cellular research to molecular research and drug innovation.Cancer stem cells,PD-1,PD-L1,immune checkpoint inhibitors,and nanoparticles are the main subjects of interest in research on breast cancer microenvironment,and the United States has the largest number of studies on breast cancer microenvironment,followed by China and Italy.Conclusion Current research mainly focuses on tumor stemness,immunotherapy,and nanodelivery.Owing to deepening research in this field,the targeting of the breast cancer microenvironment for the prevention of tumor development and metastasis and improvement of tumor prognosis has emerged as a new research direction.

关 键 词：乳腺癌微环境 机制探索 肿瘤治疗 可视化分析 CITESPACE VOSviewer 

分 类 号：R737.9[医药卫生—肿瘤]