视网膜色素变性并发白内障的临床表现与中性粒细胞/淋巴细胞计数比值的相关性  

Correlation of clinical manifestations of retinitis pigmentosa complicated with cataract and neutrophil-to-lymphocyte ratio

作　　者：何梦梅 周健 He Mengmei;Zhou Jian(Department of Ophthalmology,Xijing Hospital,Air Force Medical University,Eye Institute of PLA,Xi'an 710032,Shaanxi Province,China)

机构地区：[1]空军军医大学西京医院眼科,全军眼科研究所,陕西省西安市710032

出　　处：《国际眼科杂志》2024年第7期1114-1119,共6页International Eye Science

基　　金：国家自然科学基金项目(No.81370998);陕西省自然科学基金项目(No.2019JM-065)

摘　　要：目的:评估视网膜色素变性(RP)并发白内障患者中性粒细胞与淋巴细胞计数比值(NLR),探讨其与RP并发白内障临床特征的相关性。方法:回顾性研究。纳入2008-01/2018-12在我院接受白内障摘除手术的RP并发白内障患者79例125眼,排除发病年龄较早的RP并发白内障患者选取其中63例63眼纳入RP并发白内障组,另选取年龄、性别相匹配、同期行白内障摘除手术的年龄相关性白内障(ARC)患者63例63眼纳入ARC组。收集患者的临床资料及NLR值,分析RP并发白内障患者的临床表现与NLR相关性。结果:RP并发白内障组患者NLR显著高于ARC组[1.79(1.32,2.27)vs 1.58(1.32,1.98),P=0.032]。NLR与后囊下白内障(PSC)严重程度、悬韧带薄弱程度、术前最佳矫正视力(>1LogMAR)相关。接收者操作特征(ROC)曲线分析显示,NLR≥1.36可预测RP并发较严重的PSC(>P1)(AUC=0.803,95%CI 0.672-0.934,P=0.002),NLR≥2.12可以预测RP并发白内障患者悬韧带薄弱(AUC=0.796,95%CI 0.665-0.928,P=0.002),NLR≥1.51可以预测术前较差的BCVA(AUC=0.667,95%CI 0.540-0.793,P=0.015)。结论:RP并发白内障患者NLR明显高于ARC患者,且与RP并发白内障临床表现存在相关性。NLR可作为评估RP并发白内障临床表现严重程度的潜在预测指标。AIM:To evaluate the neutrophil-to-lymphocyte ratio(NLR)in patients with retinitis pigmentosa(RP)complicated with cataract,and to explore its correlation with the clinical characteristics of RP patients complicated with cataract.METHODS:The retrospective study included 79 RP patients(125 eyes)complicated with cataract who received cataract surgery at our hospital from January 2008 to December 2018,among which 63 cases(63 eyes)were finally enrolled in the RP complicated with cataract group after the exclusion of patients with early age of onset.Another 63 age-and sex-matched patients(63 eyes)with age-related cataract(ARC)who had cataract surgery during the same period in our hospital were enrolled in the ARC group.The clinical data and NLR were collected,and the correlation of clinical manifestations with NLR in RP patients complicated with cataract was analyzed.RESULTS:The NLR in RP patients complicated with cataract was significantly higher than that in the ARC group[1.79(1.32,2.27)vs 1.58(1.32,1.98),P=0.032].NLR was associated with the severity of posterior subcapsular cataract(PSC),zonular deficiency,and preoperative best-corrected visual acuity(>1 LogMAR).Receiver operating curve showed that NLR≥1.36 could predict higher degrees(>P1)of RP complicated PSC(AUC=0.803,95%CI 0.672-0.934,P=0.002),NLR≥2.12 could predict zonular weakness in RP patients complicated with cataract(AUC=0.796,95%CI 0.665-0.928,P=0.002),while NLR≥1.51 could predict RP patients with worse preoperative BCVA(AUC=0.667,95%CI 0.540-0.793,P=0.015).CONCLUSION:NLR in RP patients complicated with cataract is significantly higher than that in ARC patients,and it is correlated with the clinical manifestations of RP patients with cataract.NLR can be used as a potential predictor to evaluate the severity of clinical manifestations of RP complicated with cataract.

关 键 词：炎症 中性粒细胞/淋巴细胞计数比值 后囊下白内障 视网膜色素变性 悬韧带薄弱 

分 类 号：R774.1[医药卫生—眼科] R776.1[医药卫生—临床医学]