乳酸脱氢酶A在乳腺癌诊疗中的研究进展  

Advances in the study of lactate dehydrogenase A in breast cancer diagnosis and treatment

作　　者：李易飞 李文冉 刘欢 Li Yifei;Li Wenran;Liu Huan(College of Clinical Medicine,Jining Medical University,Jining 272067,China)

机构地区：[1]济宁医学院临床医学院,272067

出　　处：《中华诊断学电子杂志》2024年第2期128-132,共5页Chinese Journal of Diagnostics(Electronic Edition)

基　　金：山东省医药卫生科技发展计划项目(202104010714);济宁医学院实践教学教育研究科学项目(JYSJ2020A01)。

摘　　要：乳腺癌是一种高度异质性的恶性肿瘤,现有手段对早期乳腺癌诊断依然有限。乳酸脱氢酶A(LDHA)是参与肿瘤细胞糖酵解的关键酶,与肿瘤生长增殖、免疫逃逸、侵袭转移等恶性进展有关。有研究报道LDHA在乳腺癌中异常高表达,然而,LDHA促进乳腺癌进展的具体原因尚不完全清楚。探讨LDHA与乳腺癌进展之间的分子作用机制,对进一步探索LDHA作为新型诊断标志物、开发新型抗肿瘤药物等具有重要研究价值。笔者结合国内外最新报道,对LDHA在乳腺癌诊疗中的研究进展作一综述。Breast cancer is a highly heterogeneous malignant tumor,and the existing means for early breast cancer diagnosis remain limited.Lactate dehydrogenase A(LDHA)is a key enzyme involved in glycolysis in tumor cells,which is associated with malignant progression such as tumor growth and proliferation,immune escape,and invasion and metastasis.It has been reported that LDHA is abnormally highly expressed in breast cancer.However,the specific reasons why LDHA promotes breast cancer progression are not fully understood.Exploring the molecular mechanism between LDHA and breast cancer progression is of great value to the future exploration of LDHA as a new diagnostic marker and the development of new anti-tumor drugs.In this paper,the author summarizes the research progress of LDHA in breast cancer diagnosis and treatment based on the latest reports from home and abroad.

关 键 词：乳酸脱氢酶A 乳腺肿瘤 糖酵解 Warburg效应 

分 类 号：R737.9[医药卫生—肿瘤]