Apelin/APJ系统生理病理作用的研究进展  

Research progress on the physiological and pathological effects of apelin/APJ system

作　　者：王睿浩 姜云璐 田艳君[2] Wang Ruihao;Jiang Yunlu;Tian Yanjun(School of Mental Health,Jining Medical University,Jining 272067,China;Medical Laboratory,Jining Medical University,Jining 272067,China)

机构地区：[1]济宁医学院精神卫生学院,272067 [2]济宁医学院医学检验所,272067

出　　处：《中华诊断学电子杂志》2024年第2期138-142,共5页Chinese Journal of Diagnostics(Electronic Edition)

基　　金：山东省医药卫生科技发展计划项目(202102080596);济宁医学院大学生创新训练计划项目(cx2022129z)。

摘　　要：Apelin是一种多功能生物活性肽,通过与其受体APJ结合发挥相应生物学效应。Apelin/APJ系统作为机体重要调节者,广泛参与心血管系统、代谢系统、神经系统等方面的生理和病理过程。越来越多的研究表明,apelin/APJ系统可以作为临床防治疾病以及疾病预后的关键靶点。笔者主要对apelin/APJ系统的生理病理作用进行综述,并探讨其具体作用机制以及在临床应用方面的前景,以促进开发新型药物和寻找新的治疗策略。Apelin is a multifunctional bioactive peptide that exerts corresponding biological effects by binding to its receptor APJ.The apelin/APJ system,as an important regulator of the body,is widely involved in physiological and pathological processes of the cardiovascular system,metabolic system,nervous system,and other aspects.An increasing number of studies indicate that the apelin/APJ system can serve as a key target for prevention and control,and prognosis of clinical diseases.This article provides a review of the physiological and pathological effects of the apelin/APJ system and explores the specific mechanisms and the prospects for its clinical applications,in order to promote the development of new drugs and look for new treatment strategies.

关 键 词：APELIN APJ 生理病理作用 疾病 临床应用 

分 类 号：R363[医药卫生—病理学]