Preparation and properties of poly(ethylene glycol)-bpoly( 3-acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches  

作　　者：Yichuan HONG Haojie YU Li WANG Xiang CHEN Di SHEN Yu WANG Shuning REN Yudi HUANG Jian YANG 

机构地区：[1]State Key Laboratory of Chemical Engineering,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310058,China [2]Zhejiang-Russia Joint Laboratory of Photo-Electro-Magnetic Functional Materials,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310058,China

出　　处：《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》2024年第5期395-410,共16页浙江大学学报（英文版）A辑（应用物理与工程）

基　　金：supported by the Natural Science Foundation of Zhejiang Province(No.LHDMZ22H300003);the Science and Technology Program of Zhejiang Province(No.2019C03063),China。

摘　　要：To overcome the pain and risk of hypoglycemia in insulin administration,glucose-responsive microneedles have been developed by researchers,which could release insulin according to the blood glucose level.We designed a kind of particles by a reversible addition-fragmentation chain transfer(RAFT)method containing a phenylboronic acid group as the sensor of glucose and carrier of insulin.poly(ethylene glycol)(PEG)-2-(dodecylthio(thiocarbonyl)thio)-2-methylpropionic acid(DDMAT)was synthesized as a macromolecular RAFT agent,which was then reacted with 3-acrylamidophenylboronic acid(AAPBA)to synthesize the block copolymer PEG-b-PAAPBA.Glucose-responsive particles loaded with insulin were prepared by self-assembly based on hydrophilic-hydrophobic interactions.Microneedle patches loaded with glucose-responsive particles were prepared using hyaluronic acid as the substrate.The insulin release behavior of the particles in glucose solutions of 0,100,and 400 mg/dL showed significant glucose responsiveness and good biosafety.The results of blood glucose control experiments in rats indicate that a single microneedle patch can effectively maintain normal blood glucose for over 7 h.

关 键 词：Diabetes Hyaluronic acid Phenylboronic acid(PBA) Glucose responsive hydrogel MICRONEEDLES 

分 类 号：O63[理学—高分子化学]