阿托伐他汀联合尼莫地平治疗外伤性蛛网膜下腔出血的临床疗效观察  

Clinical Efficacy of Atorvastatin Combined with Nimodipine in the Treatment of Traumatic Subarachnoid Hemorrhage

作　　者：潘成凯 Pan Chengkai(Department of Emergency Brain Surgery,Renhuai Hospital of Traditional Chinese Medicine,Renhuai 564500,Guizhou Province,China)

机构地区：[1]仁怀市中医院急诊脑外科,贵州仁怀564500

出　　处：《中外医药研究》2024年第12期28-30,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨阿托伐他汀联合尼莫地平治疗外伤性蛛网膜下腔出血的临床疗效。方法:选择2019年3月—2023年3月仁怀市中医院收治的外伤性蛛网膜下腔出血患者94例作为研究对象,按照电脑随机编号奇偶数分为对照组和观察组,各47例。对照组采用尼莫地平治疗,观察组在对照组基础上联合阿托伐他汀治疗。比较两组临床疗效、脑动脉血流速度、血液流变学、神经功能。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.015)。治疗后,观察组脑动脉血流速度高于对照组,全血黏度、血浆黏度低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组神经功能缺损评分、神经元特异性烯醇化酶、中枢神经特异性蛋白水平低于对照组,差异有统计学意义(P<0.05)。结论:外伤性蛛网膜下腔出血采用阿托伐他汀联合尼莫地平治疗的临床疗效显著,能促进脑动脉血流改善,恢复脑灌注,减少神经功能损害。Objective:To investigate the clinical efficacy of atorvastatin combined with nimodipine in the treatment of traumatic subarachnoid hemorrhage.Methods:Ninety-four patients with traumatic subarachnoid hemorrhage admitted to Renhuai Hospital of Traditional Chinese Medicine from March 2019 to March 2023 were selected as the study subjects,and were divided into the control group and the observation group according to the computerized random numbering of odd-even numbers,each with fortyseven cases.The control group was treated with nimodipine,and the observation group was treated with atorvastatin on the basis of the control group.The clinical efficacy,cerebral arterial blood flow velocity,blood rheology,and neurological function of the two groups were compared.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.015);after treatment,the cerebral artery blood flow velocity of the observation group was higher than that of the control group,and the whole blood viscosity and plasma viscosity were lower than that of the control group,and the difference was statistically significant(P<0.05);after treatment,the neurological deficit score,neuron-specific enolase,and CNS-specific protein levels of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).Conclusion:The clinical efficacy of traumatic subarachnoid hemorrhage treated with atorvastatin combined with nimodipine is remarkable,which can promote the improvement of cerebral arterial blood flow,restore cerebral perfusion,and reduce neurological function damage.

关 键 词：外伤性蛛网膜下腔出血 阿托伐他汀 尼莫地平 血液流变学 神经功能 

分 类 号：R743.35[医药卫生—神经病学与精神病学]