杞菊润目颗粒联合双氯芬酸钠滴眼液治疗干眼症的临床研究  

Clinical study of Qiju Runmu granules combined with diclofenac sodium eye drops in the treatment ofdry eye syndrome

作　　者：韩二杰 李梦丹 王玉 徐欢 张琦 张立友 Han Erjie;Li Mengdan;Wang Yu(Department of Ophthalmology,Cangzhou Eye Hospital,Cangzhou 061000,China)

机构地区：[1]沧州市眼科医院眼科,061000

出　　处：《中华保健医学杂志》2024年第3期344-347,共4页Chinese Journal of Health Care and Medicine

基　　金：河北省医学科学研究课题计划项目(20200343)。

摘　　要：目的 探究杞菊润目颗粒联合双氯芬酸钠滴眼液治疗干眼症的临床疗效。方法 选取沧州市眼科医院2021年12月~2023年1月94例干眼症患者。按随机数字表法分为观察组(n=47)、对照组(n=47),对照组使用双氯芬酸钠滴眼液进行治疗,观察组在对照组的基础上使用杞菊润目颗粒进行治疗。比较两组患者的疗效、眼干涩、泛红、疼痛、异物感、视力模糊等中医证候积分、泪膜破裂时间(BUT)、泪液分泌(SIT)、角膜荧光素染色的变化情况。结果 与对照组(72.34%,34/47)相比,观察组患者治疗后总有效率(89.36%,42/47)显著升高,差异有统计学意义(χ^(2)=4.398,P=0.036);与治疗前相比,治疗后两组的眼干涩、泛红、疼痛、异物感、视力模糊中医症状评分、角膜荧光素染色、TGF-β1、TNF-α水平均显著降低,BUT、SIT显著升高,且与对照组相比,观察组的眼干涩、泛红、疼痛、异物感、视力模糊中医症状评分、角膜荧光素染色、TGF-β1、TNF-α水平均显著降低,BUT、SIT显著升高,差异有统计学意义(t=9.351、9.677、8.350、6.785、4.744、6.787、5.329、4.783、3.074、2.926,P<0.05)。结论 杞菊润目颗粒联合双氯芬酸钠滴眼液治疗干眼症的效果显著,可以促进患者分泌泪液,改善患者的眼部症状。Objective To explore the clinical efficacy of Qiju Runmu granules combined with diclofenac sodium eye drops in the treatment of dry eye syndrome.Methods 94 dry eye patients from our hospital from December 2021 to January 2023 were collected as the study subjects.Patients were randomly assigned to either the observation group(n=47)or the control group(n=47)using a random number table method.The control group received treatement with diclofenac sodium eye drops,while the observation group received Qiju Runmu granules in addition to the control group.The therapeutic effects,traditional Chinese medicine syndrome scores such as dry eyes,redness,pain,foreign body sensation,blurred vision,tear film rupture time(BUT),tear secretion(SIT),and changes in corneal fluorescence staining were compared between the two groups.Results Compared with the control group(72.34%,3447),the total effective rate of the observation group after treatment(89.36%,4247)was obviously increased(χ^(2)=4.398,P=0.036);compared with before treatment,the scores of traditional Chinese medicine symptom,including dry,reddish,painful,foreign body sensation,blurred vision,and the corneal fluorescence staining,the levels of TGF-β1,and TNF-αin the observation group and control group after treatment obviously decreased,BUT and SIT obviously increased,after treatment,compared with the control group,the scores of traditional Chinese medicine symptom,including dry,reddish,painful,foreign body sensation,blurred vision,and the corneal fluorescence staining,the levels of TGF-β1,and TNF-αin the observation group obviously decreased,BUT and SIT obviously increased(t=9.351,9.677,8.350,6.785,4.744,6.787,5.329,4.783,3.074,2.926,P<0.05).Conclusion The combination of Qiju Runmu granules and diclofenac sodium eye drops has a obvious effect in the treatment of dry eye syndrome,which can promote the secretion of tears in patients and improve their eye symptoms.

关 键 词：杞菊润目颗粒 双氯芬酸钠滴眼液 干眼症 泪液分泌 泪膜破裂时间 角膜荧光素染色 

分 类 号：R77[医药卫生—眼科]