Hypoglycemic Effect of Radix Et Rhizoma Salviae Miltiorrhizae,Guixi Green Tea and Their Compatibility on Mice  

作　　者：Chen YANG Zhaohui HUANG Liqing TANG Wenjing HUANG Danyu CHEN Rujun SHI Suoyi HUANG Lixiang LU Shiyou ZHOU 

机构地区：[1]School of Clinical Medicine,Youjiang Medical University for Nationalities,Baise 533000,China [2]School of Pharmacy,Youjiang Medical University for Nationalities,Baise 533000,China [3]Key Laboratory of Research on Characteristic Ethnic Medicine in the Youjiang River Basin of Guangxi Colleges and Universities,Baise 533000,China

出　　处：《Medicinal Plant》2024年第3期53-55,70,共4页药用植物：英文版

基　　金：Supported by the National Innovation Planning Project for University Students (202210599001).

摘　　要：[Objectives]To explore the hypoglycemic effect of Radix Et Rhizoma Salviae Miltiorrhizae,Guixi green tea and their compatibility on mice,so as to provide more options for the adjuvant treatment of diabetes and improve the comprehensive utilization value of Guixi green tea.[Methods]After being fed adaptively for 7 d,60 SPF-grade male mice were intraperitoneally injected with alloxouracil(180 mg/kg)to induce hyperglycemia model,from which 35 mice with a successful model were selected.They were randomly divided into 5 groups(Danshen group,green tea group,compatible group,positive control group and blank control group),with 7 animals in each group.The mice in all groups were administered according to the dose of 200 mg/kg once a day for 15 d.After the last administration,their body weight was measured on the 15 th day after fasting for 12 h,and their fasting blood glucose was measured by tail clipping.[Results]After modeling,the mice in each group showed typical hyperglycemia symptoms,namely obvious polydipsia,polyphagia,polyuria and weight loss.Compared with the blank control group,Danshen group and green tea group had obvious hypoglycemic effect(P<0.05),and compatible group had significant hypoglycemic effect(P<0.01).Compared with the blank control group,the weight loss of diabetic mice could also be inhibited in green tea group and compatible group(P<0.05).[Conclusions]Danshen,Guixi green tea and their compatibility had the effect of lowering blood sugar,among which the compatible group had the most obvious effect.

关 键 词：SALVIA miltiorrhiza Guixi green TEA Compatibility BLOOD SUGAR 

分 类 号：R285[医药卫生—中药学]