不同侧小脑梗死患者脑区比率低频振幅的改变及其与认知功能改变的关联  

Changes in the Fractional Amplitude of Low-Frequency Fluctuations in Patients with Cerebellar Infarction on Different Sides and Its Association with Cognitive Function Changes

作　　者：黄钦彬 冯兵 陈晓琪 张夏伟 HUANG Qinbin;FENG Bing;CHEN Xiaoqi(Guiping People's Hospital,Guangxi Guiping 537213,China)

机构地区：[1]广西壮族自治区桂平市人民医院神经内科,广西桂平537213

出　　处：《河北医学》2024年第6期992-997,共6页Hebei Medicine

基　　金：广西壮族自治区卫生健康委员会科研课题,(编号:Z20200212);贵港市科学研究与技术开发计划,(编号:1908002)。

摘　　要：目的:研究不同侧小脑梗死患者不同脑区域的比率低频振幅(fALFF)值的改变及其与认知功能改变的关联性。方法:回顾性研究2022年4月至2024年3月我院神经内科明确诊断的急性单侧小脑梗死的患者92例,以梗死位置分为左侧组45例与右侧组47例,另选取健康体检的受检者50例作为健康对照组,对比不同分组之间的认知功能评分,以及左侧与右侧组患者的fALFF值差异,以及不同脑区域fALFF值与认知功能的相关性。结果:小脑梗死组患者的MMSE评分、RAVLT评分、BNT评分均明显低于健康对照组(P<0.05),TMT耗时相比对照组明显延长(P<0.05)。小脑梗死组患者右侧扣带回、右侧额下回、左侧额上回、小脑后叶的fALFF值差异均相比健康对照组明显升高(P<0.05)。左侧组患者右侧扣带回、额下回、左侧额上回的fALFF值均显著高于右侧组(P<0.05),小脑后叶的fALFF值相比右侧组明显降低(P<0.05)。右侧组右侧额叶的fALFF值与MMSE评分正相关(P<0.05),右侧顶下小叶与MMSE评分负相关(P<0.05),左侧前扣带回与RAVLT评分正相关(P<0.05),左侧顶叶与TMT耗时负相关(P<0.05)。左侧组右侧前额叶、顶下小叶、扣带回与MMSE评分负相关(P<0.05),右侧顶下小叶与RAVLT评分负相关(P<0.05),右侧枕叶与RAVLT评分正相关(P<0.05),右侧顶叶与TMT耗时正相关(P<0.05)。结论:小脑梗死患者相比健康人群的认知功能明显降低,同时梗死对侧关键脑区的fALFF值表现出明显的代偿性升高,与认知功能水平相关性较强。Objective:To investigate the changes in the fractional amplitude of low-frequency fluctuations(fALFF)values in different brain regions of patients with cerebellar infarction on different sides and its association with changes in cognitive function.Methods:A retrospective study was conducted on 92 patients with acute unilateral cerebellar infarction diagnosed in the Department of Neurology of our hospital from April 2022 to March 2024.Patients were divided into left-side group(45 cases)and right-side group(47 cases)based on the location of the infarction.An additional 50 healthy individuals were selected as the healthy control group.Cognitive function scores were compared between different groups,and differences in fALFF values between the left-side and right-side groups were analyzed,along with the correlation between fALFF values in different brain regions and cognitive function.Results:The MMSE scores,RAVLT scores,and BNT scores of patients in the cerebellar infarction group were significantly lower than those in the healthy control group(P<0.05),and the TMT time was significantly prolonged compared to the control group(P<0.05).The fALFF values of the right cingulate gyrus,right inferior frontal gyrus,left superior frontal gyrus,and cerebellar posterior lobe in the cerebellar infarction group were significantly higher compared to the healthy control group(P<0.05).In the left-side group,the fALFF values of the right cingulate gyrus,inferior frontal gyrus,and left superior frontal gyrus were significantly higher than those in the right-side group(P<0.05),while the fALFF value of the cerebellar posterior lobe was significantly lower compared to the right-side group(P<0.05).In the right-side group,the fALFF value of the right frontal lobe was positively correlated with MMSE scores(P<0.05),and the right inferior parietal lobule was negatively correlated with MMSE scores(P<0.05).The left anterior cingulate gyrus was positively correlated with RAVLT scores(P<0.05),and the left parietal lobe was negatively correlated w

关 键 词：小脑梗死 脑区 比率低频振幅 认知功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]