基于主成分分析和聚类分析的多囊卵巢综合征患者中医四诊信息组合规律研究  

Information Combination Rule of TCM Four Diagnosis of Polycystic Ovary Syndrome Based on Principal Component Analysis and Cluster Analysis

作　　者：李洁韵 冯路 冯晓 林洁琪 王忆勤[1,2] 许朝霞 LI Jieyun;FENG Lu;FENG Xiao;LIN Jieqi;WANG Yiqing;XU Zhaoxia(Traditional Chinese Medicine School of Shanghai University of Traditional Chinese Medicine,Shanghai,201203,China;Shanghai Key Laboratory of Health Identification and Evaluation,Shanghai,201203,China)

机构地区：[1]上海中医药大学中医学院,上海201203 [2]上海健康辨识与评估重点实验室,上海201203

出　　处：《世界科学技术-中医药现代化》2024年第2期437-443,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：上海市科技技术委员会科技计划项目(21DZ2271000):上海市健康辨识与评估重点实验室,负责人:王忆勤。

摘　　要：目的分析多囊卵巢综合征(Polycystic ovary syndrome,PCOS)中医四诊信息组合规律,以期为PCOS中医证候分类及诊断提供参考依据。方法于2020年1月1日—2022年12月1日在上海中医药大学附属曙光医院东院、上海市中医医院妇科门诊收集PCOS患者的中医四诊信息,利用主成分分析与聚类分析方法观察四诊信息的组合规律。结果共收集349例患者的临床资料,症状频次≥10%的51项四诊信息,统计验证KMO值为0.534,Bartlett球形χ^(2)检验为5035.306(P<0.001)适宜进行主成分分析。最大方差法旋转成分矩阵对得出载荷因子,利用因子系数筛选出19个主成分对应的四诊信息,然后对19个主成分进行聚类分析,结合中医理论对聚类结果进行分析,发现气虚、气滞、火热、阴虚、阳虚、痰湿和血瘀为临床主要病性要素,常见病位要素在肾、肝和脾,可归属于肝郁脾虚证、脾肾两虚兼痰瘀互结证、脾虚湿热证、肾虚血瘀证和气滞血瘀证五种证型。结论PCOS患者中医四诊信息具有一定的组合规律,可为其证候分类规范化、标准化研究提供客观依据。Objective To explore the combination rule of the four diagnostic information of traditional Chinese medicine(TCM)of polycystic ovary syndrome(PCOS)for future classification and diagnosis.Methods The information of patients was retrospectively collected from Shuguang Hospitals Affiliated with Shanghai University of TCM and the Department of Gynecology,Shanghai Hospital of TCM from January 1,2020,to December 1,2022.Principal component analysis and cluster analysis were used to observe the combination rule of four diagnosis information.Result The KMO=0.534 and Bartlett=5035.306(P<0.001)were suitable for principal component analysis.The loading factor was obtained by rotating the component matrix pair with the maximum variance method,and the factor coefficient screened out the corresponding four diagnostic information of 19 principal components.According to the analysis of the cluster results based on the theory of TCM,the most common disease location elements were kidney,liver and spleen.It was determined that qi deficiency,qi stagnation,fire heat,yin deficiency,yang deficiency,phlegm dampness and blood stasis were the main pathogenic syndrome elements.Patients with PCOS could be classified mainly into following pattern types:Liver hyperactivity with spleen deficiency pattern;Deficiency of the spleen and kidney pattern concurrent Intertwined phlegm and blood stasis pattern;Spleen deficiency with damp heat pattern;Blood stasis of kidney deficiency pattern;Blood stasis due to qi stagnation pattern.Conclusion The four diagnostic information of PCOS patients have specific combination rules,which can provide an objective basis for the standardization and standardization of syndrome classification.

关 键 词：多囊卵巢综合征 症状组合 中医证候 主成分分析 聚类分析 

分 类 号：R-058[医药卫生]