从“脾为之卫”理论探讨肠道黏膜免疫与溃疡性结肠炎的中医机制  

To Explore the Mechanism of Intestinal Mucosal Immunity and Ulcerative Colitis in Chinese Medicine from Perspective of"Spleen as the Defense"

作　　者：马祥雪 温永天 尹晓岚 张北华[1] 唐旭东[1] MA Xiangxue;WEN Yongtian;YIN Xiaolan;ZHANG Beihua;TANG Xudong(Institute of Spleen-Stomach Disease,Xiyuan Hospital of China Academy of Chinese Medical Sciencess,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院脾胃病研究所,北京100091

出　　处：《世界科学技术-中医药现代化》2024年第3期640-645,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会青年基金项目(81804089):短链脂肪酸参与肠道菌群与宿主互动致IBS-D内脏高敏感的外周机制及肠安I号方的作用研究,负责人:马祥雪;中华中医药学会青年人才托举工程(2021-QNRC1-01):痛泻要方对PI-IBS大鼠肠道微生态-免疫与代谢组学研究,负责人:马祥雪;国家中医药管理局传承创新团队项目(ZYYCXTD-C-202010):中医药治疗难治性胃肠病的传承与创新团队,负责人:唐旭东。

摘　　要：溃疡性结肠炎(Ulcerative colitis,UC)的发病机制尚不明确,肠道黏膜免疫功能紊乱是目前研究UC发病机制的热点。脾虚是UC发病的基础,“脾为之卫”功能失常是UC肠道黏膜免疫稳态失衡的关键原因。本文以“脾为之卫”为切入点,探讨UC肠黏膜免疫功能紊乱的机制,为从脾论治UC夯实理论基础,且为从恢复肠黏膜免疫稳态角度治疗UC提供理论依据。The pathogenesis of ulcerative colitis(UC)is still unclear,and the pathogenesis based on intestinal mucosal immune imbalance is now widely recognized."Spleen as the defense"refers to the function of the spleen to protect the body and defend against pathogenic factors,which is highly consistent with modern mucosal immunology theory.The abnormal function of"Spleen as the defense"is the key reason for the immune imbalance of UC intestinal mucosa.In this paper,"spleen as the defense"as the starting point,to explore the mechanism of UC intestinal mucosal immune dysfunction,to consolidate the theoretical basis for the treatment of UC based on spleen,and to provide a theoretical basis for the treatment of UC from the perspective of restoring intestinal mucosal immune homeostasis.

关 键 词：脾为之卫 脾虚 肠道黏膜免疫 溃疡性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]