脾虚证动物模型研究述评  

A Review and Comment of Animal Models of Spleen Deficiency Syndrome

作　　者：卢梦雄 薛红[2] 张北华[2] 唐旭东[1,2] LU Mengxiong;XUE Hong;ZHANG Beihua;TANG Xudong(Peking University Traditional Chinese Medicine Clinical Medical School(Xiyuan),Beijing 100091,China;Institute of Spleen-Stomach Disease,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]北京大学中医药临床医学院(西苑),北京100091 [2]中国中医科学院西苑医院脾胃病研究所,北京100091

出　　处：《世界科学技术-中医药现代化》2024年第3期652-658,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：中国中医科学院科技创新工程创新团队(CI2021B005),负责人:唐旭东;国家自然科学基金委员会面上项目(81973838):肠内容物中短链脂肪酸通过影响Na+/Cl-转运导致乳糖不耐受脾虚证的腹泻发生机制研究及参苓白术散的干预作用,负责人:薛红。

摘　　要：中医界运用现代科学方法进行相关研究已有多年历史,在病证动物模型上颇有收获。本文对脾虚证动物模型发展历程进行回顾,对动物选择、造模方法、评价指标、消化系统病证结合模型进行总结和评论。模型动物多选用以大鼠为代表的小型啮齿类。目前,多基于病因病机造模,而较少使用化学药物与物理因素造模,复合因素造模法最常见。评价指标则分为中医证型指标、与“脾”功能和特性有关量化指标,以及方剂反证。功能性腹泻/消化不良为代表的脾虚证病证结合模型是目前研究的重心。脾虚证动物模型研究成绩斐然的同时仍存在许多不足,如缺乏脾虚证模型行业标准和共识,评价指标缺乏系统性和整体性,脾虚理论的现代阐释缺乏统一,学界亟需解决上述问题以促进发展。The field of traditional Chinese medicine has a long history of applying modern science method in related research,and has made significant achievements in the field of disease and syndrome animal models.This paper reviewed the development history of the animal model of spleen deficiency syndrome,summarized and commented the modeling method,animal selection,evaluation index,digestive system disease and syndrome combination model.Small rodents,such as rats,are commonly used as representative animal models in research.Currently,the academic community mostly focuses on etiology and pathogenesis modeling,with limited use of chemical drugs and physical factors for modeling.The most common approach is the complex factor modeling method.Evaluation indicators include traditional Chinese medicine syndrome indicators,quantitative indicators related to"spleen"function and characteristics,as well as prescription counter-indicators.The focus of current research is the combination of disease patterns related to spleen deficiency,such as functional diarrhea/dyspepsia.The research on animal models of spleen.

关 键 词：中医 脾虚证 动物模型 评价指标 病证结合 

分 类 号：R-332[医药卫生]