抑郁症患者肝-脑功能区rfMRI影像学特征及与其相关性  

Imaging Characteristics of Liver-brain Functional Area rfMRI and Its Correlation in Patients with Depression

作　　者：陈建 单秀红[2] 黄海霞 丁楷模 赵蓓 CHEN Jian;SHAN Xiu-hong;HUANG Hai-xia;DING Kai-mo;ZHAO Bei(Department of Radiology,Zhenjiang Fifth People's Hospital,Zhenjiang 212004,Jiangsu Province,China;Department of Radiology,Affiliated People's Hospital of Jiangsu University,Zhenjiang 212002,Jiangsu Province,China;Department of General Psychiatry,Zhenjiang Fifth People's Hospital,Zhenjiang 212004,Jiangsu Province,China;Department of Clinical Psychology,Zhenjiang Fifth People's Hospital,Zhenjiang 212004,Jiangsu Province,China)

机构地区：[1]镇江市第五人民医院放射科,江苏镇江212004 [2]江苏大学附属人民医院放射科,江苏镇江212002 [3]镇江市第五人民医院普通精神科,江苏镇江212004 [4]镇江市第五人民医院临床心理科,江苏镇江212004

出　　处：《中国CT和MRI杂志》2024年第6期27-30,共4页Chinese Journal of CT and MRI

基　　金：基于rfMRI的抑郁症肝-脑功能区域影像学研究(SH2022099)。

摘　　要：目的 探讨抑郁症患者肝-脑功能区静息态功能磁共振成像(rfMRI)影像学特征及与其相关性。方法 将2022年11月-2023年7月医院精神科门诊确诊的40例抑郁症发作期患者依据病情严重程度分为轻中度组、重度组,采用rfMRI记录脑区影像学信息,比较轻中度组、重度组肝-脑功能区域的影像学特征。同期选取医院进行体检的20名健康志愿者作为对照,比较健康志愿者、抑郁症患者肝-脑功能区域的影像学特征,Pearson相关性分析法评估肝-脑功能区域异常影像学特征值与抑郁症的相关性。结果 轻中度组左侧枕中回ReHo值较重度组降低,双侧楔前叶、中扣带回、杏仁核ReHo值较重度组升高,差异具有统计学意义(P<0.05)。健康志愿者左侧枕中回ReHo值较抑郁症患者降低,双侧楔前叶、中扣带回、杏仁核ReHo值较抑郁症患者升高,差异具有统计学意义(P<0.05)。Pearson相关性分析结果显示,肝-脑功能区域中左侧枕中回ReHo值与HAMD-24评分呈正相关(r=0.506,P<0.05),右侧楔前叶、左侧楔前叶、右侧中扣带回、左侧中扣带回、右侧杏仁核、左侧杏仁核ReHo值与HAMD-24评分呈负相关(r=-0.446、-0.452、-0.462、-0.481-、0.520、-0.531,P<0.05)。结论 症患者肝-脑功能异常改变的区域分布于楔前叶、枕中回、中扣带回、杏仁核,且随着抑郁症患者病情进展,枕中回ReHo值逐渐升高,楔前叶、中扣带回、杏仁核ReHo值逐渐降低,枕中回、楔前叶、中扣带回、杏仁核区域异常与抑郁症病情具有一定相关性。Objective To investigate the imaging features of liver-brain functional area by resting state functional magnetic resonance imaging(rfMRI) and its correlation in patients with depression.Methods From November 2022 to July 2023,40 patients with depression diagnosed in the psychiatric outpatient department of the hospital were divided into mild to moderate group and severe group according to the severity of the disease,rfMRI was used to record the imaging information of the brain region,and the imaging characteristics of the liver-brain function region of the mild to moderate group and the severe group were compared.During the same period,20 healthy volunteers who underwent physical examination in hospitals were selected as controls to compare the imaging characteristics of liver-brain functional regions between healthy volunteers and depressed patients,Pearson correlation analysis evaluated the correlation between abnormal imaging characteristics of liver-brain functional regions and depression.Results The ReHo value of left middle occipital gyrus in mild-moderate group was lower than that in severe group,and the ReHo value of bilateral a nterior cuneus,middle cingulate gyrus and amygdala was higher than that in severe group,with statistical significa nce(P<0.05).The ReHo value of left middle occipital gyrus in healthy volu nteers was lower than that of depressed patients,and the ReHo value of bilateral anterior cuneus,middle cingulate gyrus and amygdala was higher than that of depressed patients,with statistical significance(P<0.05).The results of Pearson correlation analysis showed that the ReHo value of the left medial occipital gyrus in the hepato-brain functional region was positively co rrelated with HAMD-24 scores(r=0.506,P<0.05),The ReHo values of the right anterior cuneus,left anterior cuneus,right middle cingulate gyrus,left middle cingulate gyrus,right amygdala,and left amygdala were negatively correlated with HAMD-24 scores(r=-0.446,-0.452,-0.462,-0.481,-0.520,-0.531,P<0.05).Conclusion The abnormal cha

关 键 词：抑郁症 肝-脑功能区 静息态功能磁共振成像 相关性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]