DCE-MRI影像特征术前区分三阴性与非三阴性乳腺癌及其与EGFR表达的相关性研究  

DCE-MRI Imaging Features of Preoperative Distinguish Three Negative and Three Negative Breast Cancer and Its Correlation with EGFR Expression Research

作　　者：曹静 彭梅娟[1] 张士朋 王彦龙 钱吉芳[1] 朱大林[1] CAO Jing;PENG Mei-juan;ZHANG Shi-peng;WANG Yan-long;QIAN Ji-fan;ZHU Da-lin(Medical Imaging Centre,Gansu Provincial Maternity and Child-care Hospital/Gansu Provincial Central Hospital,Lanzhou 730000,Gansu Province,China)

机构地区：[1]甘肃省妇幼保健院(甘肃省中心医院)医学影像中心,甘肃兰州730000

出　　处：《中国CT和MRI杂志》2024年第6期94-96,共3页Chinese Journal of CT and MRI

基　　金：甘肃省自然科学基金(21JR11RA170)。

摘　　要：目的 探讨DCE-MRI特征、瘤周、瘤内ADC值、瘤周是否水肿及血管生成术前区分三阴性乳腺癌(TNBC)与非三阴性乳腺癌(nTNBC)的诊断价值及其与EGFR表达的相关性。方法 回顾性分析甘肃省妇幼保健院经手术病理确诊的146例乳腺癌,并分为TNBC组与nTNBC组,比较两组一般临床资料、MRI特征、瘤周及瘤内ADC值、瘤周水肿、血管生成、EGFR表达的差异。结果 与nTNBC组比较,TNBC通常为圆形、边缘光整、环形强化,瘤周水肿多见、血管生成增加、EGFR高表达,且两组之间有统计学意义(P<0.05)。TNBC组的瘤周ADCmean[(1.21±0.18)×10^(-3) mm^(2)/s]、瘤内ADCmean [(0.79±0.15)×10^(-3)mm^(-2)/s]、瘤内ADCmax[(0.95±0.19)×10^(-3) mm^(-2)/s]及瘤内ADCmin[(0.63±0.004)×10^(-3)mm^(2)/s]均小于nTNBC组的瘤周ADC mean[(1.24±0.34)×10^(-3)mm^(2)/s]、瘤内ADC mean [(0.91±0.28)×10^(-)3mm^(2)/s]、瘤内ADC max[(1.06±0.32)×10^(-3)mm^(2)/s]及瘤内ADCmin[(0.78±0.02)×10^(-3)mm^(2)/s],其瘤内ADCman及瘤内ADCmin差异有统计学意义(P<0.05),瘤周ADCmean及瘤内ADCmax差异无统计学意义。结论 瘤周及瘤内ADC定量分析、肿瘤形态、内部强化方式、瘤周水肿及血管生成,可作为术前评估TNBC的影像依据,而TNBC中EGFR高表达与不良预后有关。Objective To investigate the diagnostic value of DCE-MRI characteristics,peritumoral and intratumoral ADC values,peritumor edema and preoperative angiogenesis to distinguish triple-negative breast cancer(TNBC) from non-triple-negative breast cancer(n TNBC) and their correlation with EGFR expression.Methods A retrospective analysis was performed for 146 cases of breast cancer diagnosed by surgical pathology in Gansu Maternal and Child Health Care Hospital,and divided into t NBC group and nt NBC group,and the differences in general clinical data,MRI characteristics,peritumor and intratumoral ADC values,peritumor edema,angiogenesis and EGFR expression between the two groups were compared.Results Compared with the n TNBC group,TNBC was usually round,with smooth edges,ring strengthening,peritumor edema,increased angiogenesis,and high EGFR expression,and there was a significant significance between the two groups(P<0.05).Peritumoral ADCmean [(1.21±0.18)×10^(-3)mm^(2)/s],intratumoral ADCmean [(0.79±0.15)×10^(-3)mm^(2)/s],intratumoral ADCmax [(0.95±0.19)×10^(-3)mm^(2)/s] and intratumoral ADCmin [(0.63±0.04)×10^(-3)mm^(2)/s] in the TNBC group were smaller than the peritumoral ADCmean [(1.24±] in the n TNBC group0.34)×10^(-3)mm^(2)/s],intratumoral ADCmean[(0.91±0.28)×10^(-3)mm^(2)/s],intratumoral ADCmax[(1.06±0.32)×10^(-3)mm^(2)/s]] and intratumoral ADCmin[(0.78±0.02)×10^(-3)mm^(2)/s],There were significant differences between intratumoral ADCmean and intratumoral ADCmin(P<0.05),while the difference between peritumoral ADCmean and intratumoral ADCmax was not statistically significant.Conclusion Quantitative analysis of peritumor and intratumoral ADC,tumor morphology,internal enhancement mode,peritumor edema and angiogenesis can be used as the imaging basis for preoperative evaluation of TNBC,and high EGFR expression in TNBC is associated with poor prognosis.

关 键 词：三阴性乳腺癌 非三阴性乳腺癌 EGFR 

分 类 号：R445[医药卫生—影像医学与核医学]