CT影像组学鉴别胰腺导管内乳头状黏液性肿瘤的良恶性  

CT-Based Radiomics to Differentiate Benign from Malignant Intraductal Papillary Mucinous Neoplasm

作　　者：陆晓宁 牛磊 何健[1] LU Xiao-ning;NIU Lei;HE Jian(Department of Nuclear Medicine,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,Jiangsu Province,China;Department of Imaging,Suqian Hospital Affiliated to Xuzhou Medical University,Suqian 223800,Jiangsu Province,China)

机构地区：[1]南京大学医学院附属鼓楼医院核医学科,江苏南京210008 [2]徐州医科大学附属宿迁医院影像科,江苏宿迁223800

出　　处：《中国CT和MRI杂志》2024年第6期115-117,共3页Chinese Journal of CT and MRI

摘　　要：目的 探究基于术前CT增强影像组学特征构建模型对评估胰腺导管内乳头状黏液性肿瘤的价值。方法 纳入经病理证实的51例胰腺导管内乳头状黏液性肿瘤患者。根据病理分级分为高、低危组,收集纳入者术前CT增强图像及相关临床资料,进行单因素、多因素回归分析。提取图像纹理特征,利用Lasso-Logistic回归进行特征选择,并建立回归预测模型。采用十折交叉验证评估模型,绘制预测ROC曲线。结果 临床及一般影像特征中仅筛选出一个指标即有强化壁结节进入预测模型(OR=5.980,95%CI:1.678~21.311)。于动、静脉期图像分别筛选出2、3个纹理特征,并分别构建了预测模型。临床及常规影像特征建立的预测模型AUC为0.667,动脉期的纹理模型AUC为0.801,静脉期的纹理模型AUC为0.830,动脉期联合模型的AUC为0.847,静脉期联合模型的AUC为0.859。结论 基于术前CT增强影像组学特征可以更好的鉴别良恶性IPMN,静脉期联合模型鉴别效能最优。Objective This study aimed to explore the value of analysis based on CECT radiomics in assessing intraductal papillary mucinous neoplasm(IPMN).Methods A total of 51 patients with IPMN confirmed by pathology were included.They were divided into high-risk group and low-risk groups according to pathological grading.Preope rative CECT images and relevant clinical datas were collected for univariate and multivariate regression analysis.Textural features were extra cted.Lasso-Logistic regression was used for feature selection,then Logistic regression prediction models were established.The generalization ability of the model was evaluated using ten-fold cross-validation,and the prediction ROC curve was drawn.Results Only one indicator of clinical and general imaging features,the enhanced mural nodule(OR=5.980,95%CI:1.678~21.311),is selected into the prediction model.Based on the images in arterial and venous phases,2 and 3 texture features were selected respectively.Prediction models were constructed separately.The AUC of the clinical radiological featu re model(established by clinical and conventional imaging features),the CT arterial textural feature model(established by only arterial texture featu res),the CT venous textu ral feature model(established by only venous texture features),the arterial combined model(established by arterial texture features and clinical,conventional imaging features),the venous com bined model(established by venous texture features and clinical,conventional imaging features)respectively was 0.667,0.801,0.830,0.847,0.859.Conclusion CECT-based radiomics is helpful for distinguishing malignant IPMN from benign IPMN,and the venous combined model has best performance.

关 键 词：胰腺导管内乳头状瘤 影像组学 鉴别 

分 类 号：R735.9[医药卫生—肿瘤]