曲克芦丁脑蛋白水解物联合rt-PA治疗急性脑梗死的疗效研究  

Efficacy of troxerutin cerebroprotein hydrolysate combined with rt-PA in treating acute cerebral infarction

作　　者：董芬芬 刘婷[1] 张小静 DONG Fen-fen;LIU Ting;ZHANG Xiao-jing(Department of Neurology,1.Shangluo Central Hospital,Shangluo 726000;Baoji High-Tech Hospital,Baoji 721000,Shaanxi,China)

机构地区：[1]商洛市中心医院神经内科,陕西商洛726000 [2]宝鸡高新医院神经内科,陕西宝鸡721000

出　　处：《川北医学院学报》2024年第6期803-806,共4页Journal of North Sichuan Medical College

基　　金：西安市科技计划项目[2017118SF/YX012(3)]。

摘　　要：目的:探究曲克芦丁脑蛋白水解物联合重组组织型纤溶酶原激活剂(rt-PA)治疗急性脑梗死的疗效。方法:选取193例急性脑梗死患者为研究对象,按照治疗方式不同分组,接受曲克芦丁脑蛋白水解物联合rt-PA治疗的患者为观察组(n=98),接受rt-PA静脉溶栓治疗的患者为对照组(n=95)。比较两组患者治疗期间的死亡情况和药物不良反应发生情况;治疗前和治疗后的脑血流动力学指标、脑血流灌注[脑血流容积(CBV)、脑血流量(CBF)、平均通过时间(MTT)]、血清因子水平和预后效果[美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)]。结果:在治疗期间,两组患者的药物不良反应发生率无统计学差异(P>0.05)。治疗后,两组患者的脑血流动力学指标、CBV、CBF和血清因子水平均提高,且观察组高于对照组(P<0.05);MTT、NIHSS和mRS值均较治疗前下降,且观察组低于对照组(P<0.05)。结论:采用曲克芦丁脑蛋白水解物联合rt-PA治疗急性脑梗死具有较好的疗效,能改善患者脑血流动力学指标,使脑组织血流灌注水平和血清因子水平恢复,提高预后效果。Objective:To explore the efficacy of troxerutin cerebroprotein hydrolysate combined with recombinant tissue plasminogen activator(rt-PA)in the treatment of acute cerebral infarction.Methods:193 patients with acute cerebral infarction were selected as the research subjects,and divided into two groups according to the different treatment methods.98 patients who received troxerutin cerebroprotein hydrolysate combined with rt-PA were selected as observation group,and 95 patients who underwent rt-PA intravenous thrombolysis were collected and included in control group.The death status and adverse drug reactions during treatment,cerebral hemodynamic indicators,cerebral blood perfusion[cerebral blood volume(CBV),cerebral blood flow(CBF),mean transit time(MTT)],serum factors and prognosis effect[National Institutes of Health Stroke Scale(NIHSS)score,modified Rankin Scale(mRS)]before and after treatment were compared between the two groups of patients.Results:During treatment,there were no obvious differences in the adverse drug reactions between both groups(P>0.05).The cerebral hemodynamic indicators,CBV,CBF and serum factors in the two groups after treatment were enhanced compared with those before treatment,and the above indicators in observation group were higher than those in the control group(P<0.05).MTT,NIHSS score and mRS score were reduced compared to before treatment,and the observation group was lower than the control group(P<0.05).Conclusion:Troxerutin cerebroprotein hydrolysate combined with rt-PA has a good efficacy in the treatment of acute cerebral infarction,and it can improve the recovery of cerebral hemodynamics,cerebral blood perfusion and serum factors,and enhance the prognosis effect.

关 键 词：曲克芦丁脑蛋白水解物 rt-PA治疗 急性脑梗死 脑血流灌注 血清SFAS SFASL 

分 类 号：R743.33[医药卫生—神经病学与精神病学]