锰在免疫调节中的功能及其应用  

The function and application of Manganese in immune regulation

作　　者：张沥元 李媛媛 蒋争凡[1] Zhang Liyuan;Li Yuanyuan;Jiang Zhengfan(School of Life Sciences,Peking University,Beijing 100871,China)

机构地区：[1]北京大学生命科学学院,北京100871

出　　处：《生物医学转化》2024年第2期23-29,共7页Biomedical transformation

基　　金：科技部重点研发项目(2023YFC2306102)。

摘　　要：锰是一种人体必需的微量元素,在发育、生殖、代谢、神经功能和抗氧化等方面发挥着重要的作用。近年来,锰在机体免疫中的重要作用逐步被认识和重视。锰作为一种损伤相关分子模式,具有强劲的免疫激活能力。锰离子诱导细胞产生大量的包括Ⅰ型干扰素在内的细胞因子,调控机体的天然免疫和适应性免疫反应,在免疫佐剂和肿瘤免疫治疗方面展现出巨大的潜力。本文首先总结了锰在机体内的稳态调节及其在机体免疫中的作用,之后对锰及其衍生物在免疫佐剂和肿瘤免疫治疗方面的一系列应用进行了详细的讨论,并对其未来的发展进行了展望。Manganese is an indispensable trace element in the human body,pivotal in development,reproduction,metabolism,neurological functions,and antioxidative processes.Recently,the important role of manganese in host immunity has been increasingly recognized and valued.Serving as a damage-associated molecular pattern,manganese exhibits robust immune activation capabilities.Manganese ions stimulate cells to generate numerous cytokines,including typeⅠinterferons,regulating both innate and adaptive immune responses,thus showing great potential in adjuvant and tumor immunotherapy.In this review,the homeostatic regulation of Manganese and its role in the immune response are summarized.Subsequently,it extensively explores diverse applications of manganese and its derivatives in immune adjuvants and tumor immunotherapy,and looks ahead to their future prospects.

关 键 词：锰 病毒感染 细菌感染 免疫调控 锰佐剂 肿瘤免疫疗法 

分 类 号：R730.51[医药卫生—肿瘤] Q581[医药卫生—临床医学]