鳞状细胞癌抗原联合癌胚抗原及糖类抗原-125检测对早期宫颈癌的诊断效能分析  

Analysis of diagnostic efficacy of squamous cell carcinoma antigen combined with carcinoembryonic antigen and carbohydrate antigen-125 detection for early cervical cancer

作　　者：许少花 陈立奖 卓可秀 XU Shao-hua;CHEN Li-jiang;ZHUO Ke-xiu(Clinical Laboratory of the Third People's Hospital of Cangnan County,Cangnan 325804,China)

机构地区：[1]苍南县第三人民医院检验科,浙江苍南325804 [2]龙港市人民医院检验科,浙江温州325802

出　　处：《医师在线》2024年第6期24-27,共4页Journal of Doctors Online

基　　金：苍南县科学技术局社会科学技术(医卫)项目(2023S17)。

摘　　要：目的探讨鳞状细胞癌抗原(SCC-Ag)、癌胚抗原(CEA)及糖类抗原-125(CA125)联合检测对早期宫颈癌的诊断效能。方法选取2023年1月~2023年12月我院妇科收治的宫颈上皮内瘤变(CIN)患者30例设为A组,宫颈癌患者60例(鳞腺癌10例,鳞癌35例,腺癌15例)设为B组,另选取同期健康体检者30例设为对照组。抽取所有受检者空腹静脉血,经化学发光法检测三组的SCC-Ag、CEA、CA125水平。分别对三组以及B组三种病理类型宫颈癌患者的血清SCC-Ag、CEA、CA125水平进行对比,并统计SCC-Ag、CEA、CA125单独检测及联合检测的诊断效能。结果B组的血清SCC-Ag、CEA、CA125水平均高于A组和对照组(P<0.05),A组的血清SCC-Ag、CEA、CA125水平均高于对照组(P<0.05);B组患者鳞癌的SCC-Ag水平均高于鳞腺癌和腺癌(P<0.05),腺癌的CA125、CEA水平均高于鳞腺癌和鳞癌(P<0.05);联合检测的灵敏度和准确度均高于各项指标单独检测(P<0.05),但联合检测的特异度与各项指标单独检测无明显差异(P>0.05)。结论血清SCC-Ag、CEA、CA125均对宫颈癌的诊断和预测具有一定的价值,且三种指标联合检测的灵敏度和准确度更高,可为宫颈癌的组织分期提供有利的依据,有利于后期开展治疗。Objective To investigate the diagnostic efficacy of combined detection of squamous cell carcinoma antigen(SCC-Ag),carcinoembryonic antigen(CEA)and carbohydrate antigen-125(CA125)for early cervical cancer.Methods From January 2023 to December 2023,30 patients with cervical intraepithelial neoplasia(CIN)admitted to the gynecology department of our hospital were selected as group A,60 patients with cervical cancer(10 cases of squamous adenocarcinoma,35 cases of squamous carcinoma,and 15 cases of adenocarcinoma)were selected as group B,and another 30 healthy individuals who underwent physical examinations during the same period were selected as control group.Extract fasting venous blood was collected from all subjects and the levels of SCC-Ag,CEA and CA125 were detected by chemiluminescence.Compare the serum levels of SCC-Ag,CEA and CA125 in three groups,as well as in group B with three pathological types of cervical cancer patients,and the diagnostic efficacy of SCC-Ag,CEA and CA125 detection alone and in combination were evaluated.Results The serum levels of SCC-Ag,CEA and CA125 in group B were higher than those in group A and control group(P<0.05).Serum levels of SCC-Ag,CEA and CA125 in group A were higher than those in control group(P<0.05).In group B,the SCC-Ag level of squamous cell carcinoma was higher than that of squamous adenocarcinoma and adenocarcinoma(P<0.05),the CA125 and CEA levels of adenocarcinoma were higher than those of squamou adenocarcinoma and squamous cell carcinoma(P<0.05).The sensitivity and accuracy of combined detection were higher than those of detection alone(P<0.05),but the specificity of combined detection was not significantly different from that of detection alone(P>0.05).Conclusion Serum SCC-Ag,CEA and CA125 all have certain value in the diagnosis and prediction of cervical cancer,and the combined detection of the three indexes is more sensitive and accurate,which can provide a favorable basis for the tissue staging of cervical cancer and is conducive to the later treatment.

关 键 词：早期宫颈癌 鳞状细胞癌抗原 癌胚抗原 糖类抗原-125 病理诊断 

分 类 号：R73[医药卫生—肿瘤]