膳食炎症指数与罹患癫痫风险的关系研究——基于NHANES调查数据的横断面分析  

Association between dietary inflammatory index and the risk of epilepsy:a cross-sectional analysis based on the National Health and Nutrition Examination Survey data

作　　者：张玲[1,2] 陈邓 刘凌[1] ZHANG Ling;CHEN Deng;LIU Ling(Department of Neu-rology,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院神经内科,四川成都610041 [2]成都市第八人民医院,成都医学院附属老年医院,四川成都610083

出　　处：《中风与神经疾病杂志》2024年第6期499-506,F0003,共9页Journal of Apoplexy and Nervous Diseases

摘　　要：目的采用膳食炎症指数(DII)评估膳食炎症与罹患癫痫(EP)风险的相关性,为癫痫的防治工作提供饮食方面的科学依据。方法采用2013年1月—2020年3月美国国家健康与营养检查调查(NHANES)收集的20岁及以上成年人数据。运用多元逻辑回归模型,分析DII与罹患癫痫风险的相关性,使用受限三次样条回归(RCS)进行线性试验,探索评分值与风险之间是否存在定量关系。通过亚组及交互作用分析,评估不同亚组之间DII和EP相关的稳定性。结果研究纳入15565例受访者,其中131例诊断为癫痫,在多元逻辑回归完全调整模型中,DII作为连续变量与罹患癫痫风险之间呈正相关(OR=1.12,95%CI 1.02~1.24;P=0.021);进行DII三分位后,在完全调整模型中,高促炎组的罹患癫痫风险高于低促炎组(OR=1.63,95%CI 1.02~2.6;P=0.039)。在RCS线性试验中,DII与罹患癫痫风险之间呈正相关(非线性:P=0.342)。在分层分析中,两者之间关系保持稳定,各亚组间未发现显著的交互作用。结论美国成人DII与罹患癫痫风险呈正相关,DII每增加一个单位,癫痫发生风险增加12%。Objective To investigate the association between dietary inflammation and the risk of epilepsy(EP)based on dietary inflammatory index(DII),and to provide a scientific basis for the prevention and treatment of EP in terms of dietary intervention.Methods Related data of the adults aged≥20 years were obtained from the National Health and Nutrition Examination Survey(NHANES)from January 2013 to March 2020.A multivariate logistic regression model was used to investigate the association between DII and the risk of EP,and a restricted cubic spline(RCS)regression analysis was used to perform the linearity test and explore the quantitative relationship between DII score and the risk of EP.The subgroup and interaction analyses were used to evaluate the stability of the association between DII and EP across different subgroups.Results A total of 15565 respondents were included in this study,among whom 131 were diagnosed with EP.In the fully adjusted multivariate logistic regression model,DII,as a continuous variable,was positively associated with the risk of EP[odds ratio(OR)=1.12,95%confidence interval(CI)1.02−1.24,P=0.021].After the tertile categorization of DII,the fully adjusted model showed that the high pro-inflammatory group had a significantly higher risk of EP than the low pro-inflammatory group(OR=1.63,95%CI 1.02−2.6,P=0.039).In the RCS linearity test,DII was positively associated with the risk of EP(nonlinearity:P=0.342).The stratified analysis showed that the relationship between DII and the risk of EP remained stable,with no significant interactions observed between subgroups.Conclusion There is a positive correlation between DII and the risk of EP among American adults,and for every unit increase in DII,the risk of EP is increased by 12%.

关 键 词：癫痫 膳食炎症指数 促炎饮食 抗炎饮食 

分 类 号：R742.1[医药卫生—神经病学与精神病学]