新型抗癫痫发作药物布瓦西坦作用机制及临床研究进展  

Advances in the mechanism of action and clinical studies of the novel antiepileptic drug brivaracetam

作　　者：万丽君(综述) 刘学伍(审校) WAN Lijun;LIU Xuewu(Department of Neurology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Ji-nan 250021,China)

机构地区：[1]山东第一医科大学附属省立医院神经内科,山东济南250021

出　　处：《中风与神经疾病杂志》2024年第6期507-510,F0003,共5页Journal of Apoplexy and Nervous Diseases

摘　　要：癫痫是神经系统常见疾病之一,是以脑神经元异常放电引起反复痫性发作为特征。布瓦西坦是第三代抗癫痫药物之一左乙拉西坦的类似物,通过与突触囊泡蛋白2A结合而起作用。本文就癫痫的概述、布瓦西坦在癫痫中的作用机制、药代动力学特征、临床疗效、安全性及不良反应等方面进行综述,以期为癫痫治疗提供更好的药物选择。Epilepsy is one of the common diseases of the nervous system,which is characterized by repeated epileptic seizures caused by abnormal discharge of brain neurons.Brivaracetam is an analogue of the third-generation antiepileptic drug levetiracetam and exerts a therapeutic effect by binding to synaptic vesicular protein 2A.This article reviews the disease of epilepsy and the mechanism of action,pharmacokinetic characteristics,clinical efficacy,safety,and adverse reactions of brivaracetam in epilepsy,in order to provide a better choice of drugs for the treatment of epilepsy.

关 键 词：癫痫 布瓦西坦 抗癫痫药物 突触囊泡蛋白 

分 类 号：R742.1[医药卫生—神经病学与精神病学]