伴周围神经损害的抗SRP抗体及抗GT1a抗体双阳性免疫介导坏死性肌病1例报告  

Immune-mediated necrotizing myopathy with positive anti-signal recognition particle antibody and anti-GT1a antibody accompanied by peripheral nerve injury:a case report

作　　者：张忠胜[1] 黄嘉星 孔学健 ZHANG Zhongsheng;HUANG Jiaxing;KONG Xue-jian(Department of Neurology,The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People's Hospital,Qingyuan 511518,China)

机构地区：[1]广州医科大学附属第六医院(清远市人民医院)神经内科,广东清远511518

出　　处：《中风与神经疾病杂志》2024年第6期560-562,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：抗信号识别颗粒(SRP)坏死性肌病属于免疫介导坏死性肌病(IMNM)的一种类型。该病临床少见,起病隐袭,进展较快,主要表现为对称性四肢近端无力及肌酸激酶显著升高。本文报道1例合并周围神经病变的血清抗SRP抗体及抗GT1a抗体双阳性患者,分析其临床资料及诊治经过,以提高临床医生对该病的认识。Anti-signal recognition particle(SRP)necrotizing myopathy is a type of immune-mediated necrotizing myopathy(IMNM).It is a rare disease in clinical practice and has the features of insidious onset and rapid progression,with the main manifestations of symmetrical proximal limb weakness and a significant increase in creatine kinase.This article reports a patient with positive serum anti-SRP antibody and anti-GT1a antibody accompanied by peripheral neuropathy and analyze related clinical data and diagnosis and treatment processes,in order to improve the understanding of this disease among clinicians.

关 键 词：信号识别颗粒 坏死性肌病 肢体乏力 

分 类 号：R746[医药卫生—神经病学与精神病学]