低级别嗜酸细胞肾肿瘤的临床病理学特征分析  

Clinicopathologic features of low-grade oncocytic tumor of the kidney

作　　者：岳冰[1] 张淑红[1] 柳玮华[1] 徐瑞[1] 王琳[1] 陈光勇[1] YUE Bing;ZHANG Shu-hong;LIU Wei-hua;XU Rui;WANG Lin;CHEN Guang-yong(Department of Pathology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院病理科,北京100050

出　　处：《诊断病理学杂志》2024年第3期195-198,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨低级别嗜酸细胞肾肿瘤(LOT)的临床病理学特征、免疫组织化学表达情况。方法对首都医科大学附属北京友谊医院病理科2021-06—2023-07诊断的5例(6个)LOT的临床、组织形态学、免疫表型及随访资料进行总结。结果5位患者男性1例,女性4例。肿瘤境界清楚,由紧密排列的实性小巢状结构构成,可见疏松水肿区及出血区。细胞学形态较一致,呈圆形,胞质丰富嗜酸性,可见核周空晕,WHO/国际泌尿病理协会(ISUP)分级多为2级(5/6),偶为3级(1/6)。免疫表型均为CK7阳性,CD117阴性。GATA3大多阳性(5/6),Ki-67增殖指数1%~3%。结论LOT是一种具有独特形态及免疫表型的惰性肿瘤,病理医师应当加强对于此类病变的认识,不要将其误诊为其他嗜酸细胞肿瘤。Objective To investigate the clinicopathological features and immunohistochemical expression of low-grade oncocytic tumor of the kidney(LOT).Methods The clinical,histomorphological,immunophenotypic,and follow-up data of five cases(six tumors)of LOT diagnosed in the Department of Pathology,Beijing Friendship Hospital,Capital Medical University from June 2021 to July 2023 were summarized.Results The five patients were 1 male and 4 females.The tumors were well-demarcated and consisted of compact small nests.Areas with edematous stroma and hemorrhage were commonly seen.The tumors exhibited uniform cytology with abundant eosinophilic cytoplasm.Cell nuclei featured a uniform,rounded or oval shape,with perinuclear halos evident in some areas.The majority of tumors(5/6)were classified as grade 2 by the WHO/International Society for Urological Pathology(ISUP),while one tumor was classified as grade 3.All tumors showed a positive immunophenotype for CK7 and negative for CD117,and five tumors were GATA3 positive.The Ki-67 index ranged from 1%to 3%.Conclusion LOT is a tumor with a distinctive morphology and immunophenotype that should be recognized by pathologists to prevent misdiagnosing it as other eosinophilic tumor.

关 键 词：肾肿瘤 低级别 嗜酸细胞 低级别嗜酸细胞肾肿瘤 

分 类 号：R737.11[医药卫生—肿瘤]