胃肠道钙化性纤维性肿瘤17例临床病理分析  

Calcifying fibrous tumor of the gastrointestinal tract:a clinicopathological analysis of 17 cases

作　　者：杜志华 余嘉惠 林晓丰 赵杰 杨海峰 DU Zhi-hua;YU Jia-hui;LIN Xiao-feng;ZHAO Jie;YANG Hai-feng(Department of Pathology,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510006,China;Department of Spleen and Stomach Diseases,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine/University Town Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510006,China)

机构地区：[1]广州中医药大学第二附属医院/广东省中医院病理科,广州510006 [2]广州中医药大学第二附属医院/广东省中医院大学城医院脾胃病科,广州510006

出　　处：《诊断病理学杂志》2024年第3期208-212,共5页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨胃肠道钙化性纤维性肿瘤(CFT)的临床病理学特征、免疫表型、诊断及鉴别诊断。方法收集17例胃肠道CFT的病例资料,分析其临床及病理学特征,并复习相关文献。结果女性13例,男性4例;年龄16~67岁;15例位于胃,2例位于直肠;镜下特征为大量玻璃样变胶原纤维组织,夹杂散在分布形态温和的梭形细胞,伴淋巴细胞、浆细胞浸润,多少不等的营养不良性钙化及砂砾体形成。免疫组化:部分病例瘤细胞表达CD34(3/15),1例部分表达SMA(1/16),DOG1、CD117、Desmin、S-100、ALK等均阴性。结论胃肠道CFT是一种罕见的良性纤维性肿瘤,容易误诊为消化道来源的其他间叶源性肿瘤,诊断需要结合病理学形态及免疫组化表型进行综合分析。Objective To investigate the clinicopathological features,immunophenotype,diagnosis and differential diagnosis of calcifying fibrous tumor(CFT)of the gastrointestinal tract.Methods We collected 17 gastrointestinal CFT cases,analyzed their clinical and pathological characteristics,and reviewed relevant literature.Results There were 13 females and 4 males.The age ranged from 16 to 67 years.Fifteen tumors were located in the stomach and 2 in the rectum.Microscopically,the tumor was characterized by a large amount of hyalinized collagen fibers interspersed with mildly distributed spindle cells,accompanied by infiltration of lymphocytes and plasma cells,variable amounts of dystrophic calcifications and psammoma bodies.Immunohistochemically,the tumor cells were positive for CD34(3/15)and SMA(1/16),but negative for DOG1,CD117,Desmin,S-100 and ALK.Conclusion CFT of the gastrointestinal tract is a rare benign fibrous tumor,which is easily misdiagnosed as other mesenchymal tumors derived from the digestive tract.Comprehensive analysis of pathological morphology and immunohistochemistry is necessary for the diagnosis.

关 键 词：钙化性纤维性肿瘤 诊断 鉴别诊断 胃肿瘤 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤] R735.3[医药卫生—临床医学]