甲状腺结节BRAF基因突变检测在指导甲状腺癌全切手术中的作用  

Role of BRAF gene mutation detection in thyroid nodules in guiding total thyroid cancer surgery

作　　者：刘洁 蔡文卿 苑冬旭 刘晓莉[1] Liu Jie;Cai Wenqing;Yuan Dongxu;Liu Xiaoli(Department of Thyroid Surgery,China-Japan Union Hospital of Jilin University,Changchun 130033,China)

机构地区：[1]吉林大学中日联谊医院甲状腺外科,长春130033

出　　处：《国际外科学杂志》2024年第5期349-354,共6页International Journal of Surgery

基　　金：吉林省卫生科研人才专项项目(2023SCZ37)。

摘　　要：甲状腺癌是一种常见的内分泌系统恶性肿瘤,近年来其发病率显著增加。手术治疗是甲状腺癌最重要的初始治疗手段,但甲状腺全切手术在延长患者无病生存期,降低疾病复发风险和减少残留病灶的同时,增加了术后低血钙和喉返神经损伤的风险。因此,如何根据术前检查结果做出最佳手术决策仍处于争议之中。BRAF作为甲状腺恶性肿瘤中常见的基因突变之一,与肿瘤的恶性程度和预后密切相关。术前行BRAF基因检测有助于判断甲状腺肿瘤侵袭性病理特征,为临床医师决定手术切除范围提供科学的指导。本文将就BRAF基因突变检测结果在甲状腺癌全切手术中的指导作用进行综述。Thyroid carcinoma is a common malignant tumor of the endocrine system and its incidence has increased significantly in recent years.Surgery is the most important initial treatment for thyroid cancer,but total thyroidectomy increases the risk of postoperative hyponatremia and recurrent laryngeal nerve injury while prolonging the disease-free survival of patients,decreasing the risk of disease recurrence and reducing residual lesions.Therefore,how to make the best surgical decision based on preoperative findings is still controversial.V-raf murine sarcoma viral oncogene homolog B1(BRAF),as one of the common genetic mutations in thyroid malignant tumors,is closely related to the degree of malignancy and prognosis of the tumor.Preoperative BRAF gene testing can help determine the aggressive pathological features of thyroid tumors and provide scientific guidance for clinicians to decide the scope of surgical resection.This article reviews the guiding role of BRAF gene mutation detection results in total thyroid cancer resection.

关 键 词：甲状腺肿瘤 甲状腺切除术 综述 BRAF 

分 类 号：R736.1[医药卫生—肿瘤]