纤维蛋白原纤维蛋白原、糖类抗原糖类抗原125125、人附睾蛋白人附睾蛋白4联合检测对早期卵巢癌的诊断价值  

Diagnostic value of fibrinogen,carbohydrate antigen 125 and human epididymis protein 4 combined detection in early ovarian cancer

作　　者：邢丹 郭佳 陈仪 XING Dan;GUO Jia;CHEN Yi(Department of Laboratory Medicine,Zhumadian Central Hospital,Zhumadian 463000,He’nan,China)

机构地区：[1]驻马店市中心医院医学检验科,河南驻马店4630000

出　　处：《癌症进展》2024年第9期991-994,共4页Oncology Progress

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200834)。

摘　　要：目的目的探讨纤维蛋白原(FIB)、糖类抗原125(CA125)、人附睾蛋白4(HE4)联合检测对早期卵巢癌的诊断效能。方法方法选取102例早期卵巢癌患者和100例卵巢良性病变患者,分别作为卵巢癌组和对照组,比较两组患者、不同临床分期卵巢癌患者的血清FIB、CA125、HE4水平。以病理检查结果为金标准,评估FIB、CA125、HE4单独及联合检测对早期卵巢癌的诊断价值。结果结果卵巢癌组患者血清FIB、CA125、HE4水平均明显高于对照组,Ⅱ期卵巢癌患者血清FIB、CA125、HE4水平均明显高于Ⅰ期患者,差异均有统计学意义(P﹤0.01)。血清FIB、CA125、HE4联合检测诊断早期卵巢癌的灵敏度、特异度、阳性预测值、阴性预测值、准确度分别为92.16%、85.00%、86.24%、91.40%、88.61%,其中灵敏度和阴性预测值均高于各指标单独检测。结论结论FIB、CA125、HE4联合检测诊断早期卵巢癌的效能较高,可为卵巢癌的早期诊断提供可靠的理论依据。Objective To explore the diagnostic value of fibrinogen(FIB),carbohydrate antigen 125(CA125)and hu-man epididymis protein 4(HE4)combined detection in early ovarian cancer.Method A total of 102 patients with early ovarian cancer and 100 patients with benign ovarian disease were selected as the ovarian cancer group and the control group,respectively.The levels of serum FIB,CA125 and HE4 were compared between the two groups and the ovarian cancer patients with different clinical stages.The pathological examination result was considered as the gold standard,the diagnostic value of FIB,CA125 and HE4 single and combined detection for early ovarian cancer were evaluated.Result The serum FIB,CA125,and HE4 levels in the ovarian cancer group were significantly higher than those in the control group,and the serum FIB,CA125,and HE4 levels in ovarian cancer patients with stage II were significantly higher than those in patients with stage I,and the differences were statistically significant(P<0.01).The sensitivity,specificity,posi-tive predictive value,negative predictive value,and accuracy of serum FIB,CA125 and HE4 combined detection in diag-nosing early ovarian cancer were 92.16%,85.00%,86.24%,91.40%and 88.61%,respectively,and the sensitivity and neg-ative predictive value were higher than those of single detection of each indicator.Conclusion The FIB,CA125 and HE4 combined detection has high efficiency in diagnosing early ovarian cancer,and can provide reliable theoretical basis for early diagnosis of ovarian cancer.

关 键 词：早期卵巢癌 纤维蛋白原 糖类抗原125 人附睾蛋白4 

分 类 号：R737.31[医药卫生—肿瘤]