人附睾蛋白4、磷酸酶张力蛋白同源物磷酸酶张力蛋白同源物、Ki-Ki-6767在卵巢癌中的表达及与患者临床特征和预后的关系  

Expression of human epididymis protein 4,phosphatase and tensin homolog,Ki-67 in ovarian cancer patients and their relationship with clinical characteristics and prognosis

作　　者：王英[1] 徐燕 王娜[1] WANG Ying;XU Yan;WANG Na(Department of Gynecology,Nanyang Central Hospital,Nanyang 473000,He’nan,China)

机构地区：[1]南阳市中心医院妇科,河南南阳4730000

出　　处：《癌症进展》2024年第9期1025-1028,共4页Oncology Progress

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200050)。

摘　　要：目的目的探讨人附睾蛋白4(HE4)、磷酸酶张力蛋白同源物(PTEN)、Ki-67在卵巢癌中的表达及与患者临床特征和预后的关系。方法方法选取83例卵巢癌患者和75例卵巢良性病变患者,分别作为卵巢癌组和卵巢良性病变组,比较两组患者及不同临床特征卵巢癌患者HE4、PTEN、Ki-67阳性表达情况。根据预后情况将卵巢癌患者分为预后良好组和预后不良组,采用Logistic回归模型分析卵巢癌患者预后的影响因素。结果结果卵巢癌组患者HE4、Ki-67阳性表达率均明显高于卵巢良性病变组,PTEN阳性表达率明显低于卵巢良性病变组,差异均有统计学意义(P﹤0.01)。不同分化程度、TNM分期、远处转移情况卵巢癌患者HE4、Ki-67、PTEN阳性表达率比较,差异均有统计学意义(P﹤0.05)。单因素分析结果显示,预后良好组(n=71)和预后不良组(n=12)患者分化程度、TNM分期、远处转移情况及HE4、PTEN、Ki-67表达情况比较,差异均有统计学意义(P﹤0.05)。多因素Logis-tic回归分析结果显示,分化程度、TNM分期、远处转移情况及HE4、PTEN、Ki-67表达情况均是卵巢癌患者预后的影响因素(P﹤0.05)。结论结论HE4、PTEN和Ki-67参与了卵巢癌的发生发展,是卵巢癌患者预后的影响因素。Objective To investigate the expression of human epididymis protein 4(HE4),phosphatase and tensin ho-molog(PTEN),Ki-67 in ovarian cancer patients and their relationship with clinical characteristics and prognosis.Method A total of 83 patients with ovarian cancer and 75 patients with benign ovarian disease were selected as ovarian cancer group and benign ovarian disease group,respectively.The positive expression of HE4,PTEN and Ki-67 in two groups and ovarian cancer patients with different clinical characteristics were compared.The patients with ovarian cancer were divided into good prognosis group and poor prognosis group according to the prognosis,and the influencing factors of prognosis were analyzed by Logistic regression model.Result The positive expression rates of HE4 and Ki-67 in ovari-an cancer group were significantly higher than those in benign ovarian disease group,and the positive expression rates of PTEN was significantly lower than that in benign ovarian disease group,and the differences were statistically significant(P<0.01).The positive expression rates of HE4,Ki-67,and PTEN in ovarian cancer patients with different differentiation degrees,TNM stages,and distant metastasis were compared,and the differences were statistically significant(P<0.05).Univariate analysis showed that the differentiation degree,TNM stage,distant metastasis and expression of HE4,PTEN and Ki-67 of the good prognosis group(n=71)and the poor prognosis group(n=12)were compared,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that the differentiation degree,TNM stage,distant metastasis and the expression of HE4,PTEN and Ki-67 were prognostic factors of ovarian cancer pa-tients(P<0.05).Conclusion HE4,PTEN and Ki-67 are involved in the occurrence and development of ovarian cancer and are influencing factors for the prognosis of ovarian cancer patients.

关 键 词：卵巢癌 人附睾蛋白4 磷酸酶张力蛋白同源物 Ki-67 预后 

分 类 号：R737.31[医药卫生—肿瘤]