血清白细胞介素6对脑出血患者预后的影响  

Effect of serum interleukin-6 on prognosis of patients with cerebral hemorrhag

作　　者：魏广 王芬 齐林[1] 周丽平 WEI Guang;WANG Fen;QI Lin;ZHOU Li-ping(Department of Clinical Laboratory,the Seventh Peoples Hospital of Zhengzhou,Zhengzhou 450000,China;Department of Blood Transfusion,the Seventh Peoples Hospital of Zhengzhou,Zhengzhou 450000,China;Department of Neurology,the Seventh Peoples Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市第七人民医院检验科,郑州450000 [2]郑州市第七人民医院输血科,郑州1450000 [3]郑州市第七人民医院神经内科,郑州450000

出　　处：《医药论坛杂志》2024年第10期1014-1018,1023,共6页Journal of Medical Forum

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210746)。

摘　　要：目的 探讨脑出血(intra cerebral hemorrhage, ICH)患者入院时血清白细胞介素6(interleukin 6,IL-6)水平与其病情程度和预后的相关性。方法 选取郑州市第七人民医院2020年1月—2022年3月收治的脑出血患者602例,在患者入院4 h内检测血清IL-6水平,根据IL-6水平分为四组。IL-6水平四分位数范围如下:Q1为0.95~2.51 ng/L;Q2为2.54~4.47 ng/L;Q3为4.49~8.35 ng/L;Q4为8.38~286.55 ng/L。应用回归分析评估基线血清IL-6水平对患者90 d功能预后的影响。应用相关分析探讨基线血清IL-6水平和患者入院时脑出血量及血肿周围水肿(perihematomal edema, PHE)体积之间的关系。结果 (1) Q1、Q2、Q3、Q4等四个组的基线资料相比,年龄、糖尿病、收缩压、舒张压、GCS评分、ICH位置、ICH量、PHE体积、脑室出血、凝血酶原时间、活化部分凝血活酶时间、血浆纤维蛋白原等12个指标差异有统计学意义(P<0.05)。(2)多因素logistic回归结果:年龄大、收缩压高、糖尿病、ICH量大、GOS评分低、血清IL-6水平高是患者发病后90 d预后不良的危险影响因素(P<0.05,OR>1)。(3) Pearson相关显示:患者入院时IL-6水平和基线ICH及基线PHE体积均具有正相关性(r分别为0.519、0.360,P<0.001)。结论 入院时血清IL-6与ICH患者较差的90 d功能结果、入院时较多的脑出血量和较大的血肿周围水肿相关。Objective To investigate the relationship between the level of serum interleukin-6(IL-6) and the severity and prognosis of patients with intra cerebral hemorrhage(ICH).Methods A total of 602 patients with cerebral hemorrhage admitted to Seventh People's Hospital of Zhengzhou from January 2020 to March 2022 were selected. Serum IL-6 levels were detected within 4h after admission, and the patients were divided into four groups according to IL-6 levels: Q1(0.95-2.51) ng/L;Q2(2.54-4.47) ng/L;Q3(4.49-8.35) ng/L;Q4 is(8.38-286.55) ng/L. Regression analysis was used to evaluate the effect of baseline serum IL-6 level on the 90d functional prognosis of patients. Correlation analysis was used to investigate the relationship between baseline serum IL-6 level and intracerebral hemorrhage volume and perihematoma edema(PHE) volume at admission.Results(1)There were significant differences in baseline data of 4 groups, such as Q1, Q2, Q3, Q4, age, diabetes, systolic blood pressure, diastolic blood pressure, GCS score, ICH location, ICH volume, PHE volume, ventricular hemorrhage, prothrombin time, activated partial thromboplastin time, fibrinogen, 12 indicators, there were significant differences, P<0.05.(2)Multiple logistic regression results: age, systolic blood pressure, diabetes, ICH, GOS score and serum IL-6 level were the risk factors of poor 90d prognosis(P<0.05, OR>1).(3) Pearson correlation showed that there was a positive correlation between IL-6 level and baseline ICH and baseline PHE volume at admission(r=0.519,0.360, P<0.001).Conclusion Serum IL-6 at admission is associated with poor 90 d functional results, more ICH at admission and greater PHE.

关 键 词：白细胞介素6 脑出血 预后 

分 类 号：R743.34[医药卫生—神经病学与精神病学]