LIVIN和SMAC在鼻腔鼻窦内翻性乳头状瘤的表达及其意义  

Expression And Sense Of Livin And Smac Protein In Sinonasal Inverted Papilloma

作　　者：周荣荣 Zhou Rongrong(Liaocheng Infectious Disease Hospital Liaocheng,Shandong,252000,China)

机构地区：[1]聊城市传染病医院,山东聊城252000

出　　处：《中国医学文摘（耳鼻咽喉科学）》2024年第3期94-99,I0002,共7页Chinese Medical Digest(Otorhinolaryngology)

摘　　要：目的内翻性乳头状瘤(SNIP)的发生以及复发和恶变的分子病理机制尚未明确阐明。本实验是利用检测凋亡抑制蛋白Livin与促凋亡蛋白Smac在SNIP的表达情况,探索两者在该病发病中的相互作用,以此进一步寻找新的诊断方法、治疗方式。方法采取免疫组化法来检测出实验组38例SNIP组织和对照组16例正常鼻腔黏膜组织(NM)以及15例鼻腔鳞状细胞癌(NSCC)组织中Livin和Smac蛋白表达情况。根据实验结果中组织细胞的染色强度和染色率,运用SPSS21.0统计软件来分析实验结果,以P<0.05为有统计学意义,来判断Livin和Smac在SNIP中的表达情况,依此来分析两者与SNIP的病理特征的关系及两者在肿瘤中的表达的相关性。结果Livin在NSCC的表达高于SNIP,在SNIP中的表达高于NM。Smac在NSCC中的表达低于SNIP,在SNIP中的表达低于NM。Livin和Smac蛋白在SNIP中的表达与患者的年龄、性别、肿瘤大小无关,和肿瘤的临床分期和是否为复发性肿瘤有关系。二者在SNIP的表达呈负相关,其相关指数rs=-0.41(P<0.05)。结论Livin和Smac有成为SNIP的肿瘤标志物及判断肿瘤是否复发及癌变的指标的可能性。Livin和Smac在SNIP中的表达呈负相关,且和SNIP的复发和恶变有关系,检测其表达可以判断其是否复发和预后,有可能成为肿瘤治疗中的新靶点。Objective The occurrence of Inverted papilloma and the molecular mechanism of recurrence and canceration have not been clearly elucidated.This experiment aims to research Livin and Smac in SNIP and study the expression level and study the correlation between the two,in order to seek theoretical and experimental evidence for the pathogenesis of SNIP judge the malignant degree and the assessment of prognosis.Methods:Immunohistochemical method was used to detect the expression of Livin and Smac in the experimental group of 38 cases SNIP and the control group 16 cases of normal nasal mucosa(NM)and 15 cases of Sinonasal squamous cell carcinoma(NSCC).According to the staining strength and staining rate of the cells in the experimental results,the SPSS 21.0 software was used to analyze the experimental results,and P<0.05 was recognized as statistical significance to determine the expression of the SNIP.Results:It can be considered that the expression of Livin in NSCC is higher than SNIP,and the expression in SNIP is higher than NM.The expression of Smac in NSCC is lower than SNIP,and the expression in SNIP is lower than NM.It is confirmed that the positive expression of Livin and Smac protein in SNIP was not correlated with the age,sex,tumor size;It was related with the clinical classification,whether for recurrent tumor..In SNIP,The expression in SNIP was negatively correlated,rs=-0.41(P<0.05).Conclusion:1.Livin and Smac protein may be tumor markers of SNIP and judge tumor relapse.Livin and Smac are negatively correlated with the expression of SNIP,and have a relationship with the relapse and malignant transformation of SNIP.The detection of its expression can determine whether it has recurrence and prognosis,and may be a new target in tumor therapy.

关 键 词：LIVIN SMAC 内翻性乳头状瘤 鼻腔鳞状细胞癌 正常鼻腔黏膜组织 免疫组化 

分 类 号：R73[医药卫生—肿瘤]