单核吞噬细胞在年龄相关性黄斑变性发病机制中的研究进展  

Research progress of mononuclear phagocytes in the pathogenesis of age-related macular degeneration

作　　者：杨凌齐 吕洋 YANG Lingqi;LYU Yang(The First Clinical Medical School,Gansu University of Chinese Medicine,Lanzhou 730050,China;The 940 Hospital of Joint Service Support Forces of the Chinese People's Liberation Army,Lanzhou 730050,China;Basic Medical Laboratory of the 940 Hospital of the Chinese People's Liberation Army Joint Logistic Support Force,Gansu Key Laboratory of Stem Cell and Gene Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃省中医药大学第一临床医学院,兰州730000 [2]中国人民解放军联勤保障部队第940医院眼科中心,兰州730050 [3]中国人民解放军联勤保障部队第940医院基础医学实验室、甘肃省干细胞与基因药物重点实验室,兰州730050

出　　处：《国际免疫学杂志》2024年第3期289-293,共5页International Journal of Immunology

基　　金：国家自然科学基金(82000926);甘肃省卫生健康行业科研项目(GSWSKY2022-05);中国人民解放军联勤保障部队第九四〇医院基金(2021yxky033,2023YXKY011,2023YXKY033)。

摘　　要：年龄相关性黄斑变性(age related macular degeneration,AMD)是一种涉及年龄、遗传和环境等多因素相互作用导致的视网膜黄斑疾病。单核吞噬细胞(mononuclear phagocytes,MPs)是常驻视网膜血管周围的天然免疫细胞群,在正常眼部组织中发挥吞噬、清除等功能。但在AMD病变中,因视网膜色素上皮(retinal pigment epithelium,RPE)细胞及光感受器功能障碍,代谢产物异常堆积,启动视网膜常驻MPs发生免疫炎症反应,形成眼底炎症微环境,促使AMD进展。文章综述了MPs表面标志物、趋化因子及其受体对RPE的影响以及MPs与RPE细胞相互作用对AMD疾病发展的影响。Age-related macular degeneration(AMD)is a retinal macular disease caused by the interaction of age,genetics,environment and other factors.Mononuclear phagocytes(MPs)are a population of innate immune cells that reside around the retinal blood vessels and play a role in phagocytosis and clearance in normal ocular tissues.However,due to the retinal pigment epithelium(RPE)cells and photoreceptors dysfunction in AMD lesions,abnormal accumulation of metabolites triggers immune inflammatory reactions in retinal resident MPs,forming a retinal inflammatory microenvironment,and promote the progression of AMD.This review summarizes the effects of MPs surface markers,chemokines and their receptors on RPE,as well as the interaction between MPs and RPE cells on the development of AMD disease.

关 键 词：年龄相关性黄斑变性 单核吞噬细胞 趋化因子 视网膜色素上皮 

分 类 号：R774.5[医药卫生—眼科]