通腑逐瘀方联合常规西药治疗腑实热结证急性胰腺炎临床研究  

Clinical Study on Tongfu Zhuyu Decoction Combined with Conventional Western Medicine for Acute Pancreatitis with Syndrome of Bowel Excess and Heat Bind

作　　者：李芝萍 汪娅君[1] 张菊萍 徐涛 李俊华 LI Zhiping;WANG Yajun;ZHANG Juping;XU Tao;LI Junhua(Quzhou People's Hospital,Quzhou Zhejiang 324000,China)

机构地区：[1]衢州市人民医院,浙江衢州324000

出　　处：《新中医》2024年第10期81-85,共5页New Chinese Medicine

摘　　要：目的:观察通腑逐瘀方辅助西药治疗腑实热结证急性胰腺炎的临床疗效。方法:选择98例急性胰腺炎患者,按随机数字表法分为联合组和对照组各49例。对照组给予常规西医治疗,联合组在对照组基础上联合通腑逐瘀方治疗。治疗7 d后,比较2组临床疗效、中医证候评分、临床症状恢复时间、炎症因子和肠黏膜屏障功能指标变化。结果:治疗后,联合组总有效率为93.88%,对照组为79.59%,2组比较,差异有统计学意义(P<0.05)。治疗后,联合组腹胀缓解时间、腹痛减轻时间、肠鸣音恢复时间、首次排气时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,2组主、次症中医证候评分及总分均较治疗前降低(P<0.05),且联合组主、次症评分及总分均低于对照组(P<0.05)。治疗后,2组白细胞计数(WBC)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)水平较治疗前降低(P<0.05),且联合组3项指标水平均低于对照组(P<0.05)。治疗后,2组二胺氧化酶(DAO)、D-乳酸、内毒素水平均较治疗前降低(P<0.05),且联合组3项指标水平均低于对照组(P<0.05)。结论:通腑逐瘀方联合常规西药治疗急性胰腺炎,可以进一步提高疗效,改善中医证候,加快临床症状康复,减轻炎症反应并改善肠黏膜屏障功能。Objective:To observe the effect of the therapy of Tongfu Zhuyu Decoction combined with conventional western medicine for acute pancreatitis with syndrome of bowel excess and heat bind.Methods:A total of 98 patients with acute pancreatitis were selected and divided into the combination group and the control group according to the random number table method,with 49 cases in each group.The control group was given conventional western medicine,and the combination group was treated with Tongfu Zhuyu Decoction on the basis of the control group.After 7 days of treatment,the clinical effects,traditional Chinese medicine(TCM)syndrome scores,recovery time of clinical symptoms,inflammatory factors and intestinal mucosal barrier function indexes were compared between the two groups.Results:After treatment,the total effective rate was 93.88%in the combination group,and 79.59%in the control group,the difference being significant(P<0.05).After treatment,the abdominal distension relief time,abdominal pain relief time,bowel sound recovery time and first exhaust time in the combination group were shorter than those in the control group,differences being significant(P<0.05).After treatment,the primary and secondary syndrome scores and total scores in the two groups were decreased when compared with those before treatment(P<0.05),and the primary and secondary syndrome scores and the total score in the combination group were lower than those in the control group(P<0.05).After treatment,the levels of white blood cell count(WBC),C-reactive protein(CRP)and interleukin-6(IL-6)in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of the three inflammatory factors in the combination group were lower than those in the control group(P<0.05).After treatment,the levels of diamine oxidase(DAO),D-lactic acid and endotoxin in the two groups were decreased when compared with those before treatment(P<0.05),and the above three indicators in the combination group were lower than those in the control group(P

关 键 词：急性胰腺炎 腑实热结证 通腑逐瘀方 炎症因子 肠黏膜屏障功能 

分 类 号：R576[医药卫生—消化系统]