幽门螺杆菌相关胃外疾病研究进展  

Research Progress of Helicobacter pylori-Associated Extragastric Diseases

作　　者：刘晋阳 陈峥宏 马牧溪 林永帅 谭伟伟 LIU Jinyang;CHEN Zhenghong;MA Muxi;LIN Yongshuai;TAN Weiwei(Clinical Medicine School,Guizhou Medical University,Guiyang 550001,China;Department of Urology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550001,China;Helicobacter pylori and Intestinal Microecology Joint Laboratory/Department of Urology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550001,China;Key Laboratory of Pathogenic Biology Characteristics,Guizhou Provincial Department of Education,Guiyang 550001,China;Central Hospital of Yicheng District in Zhumadian,Zhumadian,Henan 463000,China)

机构地区：[1]贵州医科大学临床医学院,贵阳550001 [2]贵州医科大学附属医院泌尿外科,贵阳550001 [3]贵州医科大学附属医院泌尿外科/幽门螺杆菌与肠道微生态联合实验室,贵阳550001 [4]贵州省教育厅病原生物学特色重点实验室,贵阳550001 [5]河南省驻马店市驿城区中心医院,河南驻马店463000

出　　处：《中国医学科学院学报》2024年第3期414-424,共11页Acta Academiae Medicinae Sinicae

基　　金：贵州省科技计划项目[黔科合基础-ZK(2022)一般341];贵州省卫生健康委科学技术基金(gzwkj 2022-521)。

摘　　要：幽门螺杆菌(Hp)是一种常见的胃肠道感染的革兰氏阴性杆菌,主要存在于胃上皮细胞表面和黏液中,与胃溃疡、胃癌和胃黏膜等相关淋巴瘤有关。研究表明Hp可诱发或加重某些胃外疾病,还与新型冠状病毒感染发生有关,因此Hp可能通过刺激机体产生炎症因子或发生交叉免疫反应,间接或直接地参与胃外疾病的发生和发展,同时Hp还可进入念珠菌内,持续释放毒素,且发挥躲避免疫系统识别和药物杀菌作用。本文总结近年国内外对Hp相关胃外疾病的研究报道,旨在引起临床工作者对Hp相关胃外疾病的重视,积极地掌握Hp的感染相关学科知识,从而科学制订避免Hp加重或诱发其他疾病的对策。Helicobacter pylori(Hp)is a common Gram-negative bacillus causing gastrointestinal infections.It mainly exists on the surface of gastric epithelial cells and in mucus and is associated with gastric ulcers,gastric cancer,and gastric mucosa-associated lymphomas.Studies have shown that Hp can induce or exacerbate certain extragastric diseases and is associated with the occurrence of coronavirus disease 2019.It is hypothesized that Hp may be indirectly or directly involved in the occurrence and development of diseases by stimulating the production of inflammatory cytokines or inducing cross-immune reactions.In addition,Hp can enter Candida to release toxins continuously and play a role in escaping the recognition of the host immune system and the bactericidal effect of drugs.This article reviews the research progress in Hp-associated extragastric diseases in recent years,aiming to draw the attention of clinical workers to Hp-associated extragastric diseases and enrich the knowledge about Hp infection for formulating countermeasures to avoid the aggravation or triggering of other diseases by Hp.

关 键 词：幽门螺杆菌 胃外疾病 交叉免疫反应 新型冠状病毒感染 

分 类 号：R573[医药卫生—消化系统]