酪酸梭菌活菌胶囊联合伊托必利对功能性消化不良患者的疗效及胃肠激素的影响  

Effect of Clostridium butyricum capsule combined with itopride on gastrointestinal hormones in patients with functional dyspepsia

作　　者：李双 李颖[2] 谢菲 LI Shuang;LI Ying;XIE Fei(Department of Pharmacy,Xidian Group Hospital,Xi'an 710077,China;Department of Center of Endoscope,Shaanxi Provincial People's Hospital,Xi'an 710068,China)

机构地区：[1]西电集团医院药剂科,陕西西安710077 [2]陕西省人民医院腔镜中心,陕西西安710068

出　　处：《国际消化病杂志》2024年第3期175-179,210,共6页International Journal of Digestive Diseases

摘　　要：目的探究酪酸梭菌活菌胶囊联合伊托必利对功能性消化不良(FD)患者的疗效及胃肠激素的影响。方法选择2021年11月至2022年12月西电集团医院收治的82例FD患者作为研究对象,采用随机数表法将患者分为观察组和对照组,每组各41例。对照组口服盐酸伊托必利治疗,观察组在此基础上口服酪酸梭菌活菌胶囊治疗,所有患者均连续治疗3个月。分别采用7分整体症状量表(GOSS)和功能性消化不良生存质量量表(FDDQL)评估2组治疗前后的临床症状和生活质量。采用放射免疫分析法检测血清促胃泌素(GAS)、5-羟色胺(5-HT)和胃动素(MLT)水平。比较2组治疗3个月后的临床有效率。结果与同组治疗前相比,治疗3个月后2组的GOSS评分和5-HT水平均降低,而FDDQL评分、GAS和MLT水平均升高,差异均有统计学意义(P均<0.05)。治疗3个月后,观察组的GOSS评分和5-HT水平均低于对照组,而FDDQL评分、GAS和MLT水平均高于对照组,差异均有统计学意义(P均<0.05)。治疗3个月后,观察组的临床有效率为95.12%,显著高于对照组(78.05%),差异有统计学意义(P<0.05)。结论酪酸梭菌活菌胶囊联合伊托必利可有效缓解FD患者的消化道症状,促进胃肠蠕动功能恢复并提高临床疗效,有利于提高FD患者的生活质量,具有一定的临床推广价值。Objective This paper intends to investigate the effect of Clostridium butyricum capsule combined with itopride on gastrointestinal hormones in patients with functional dyspepsia(FD).Methods A total of 82 FD patients who were admitted to Xidian Group Hospital from November 2021 to December 2022 were randomly assigned to the observation group(n=41)and the control group(n=41).The control group was treated with itopride hydrochloride,while the observation group was treated with Clostridium butyricum capsule combined with itopride hydrochloride.All patients were treated continuously for 3 months.The 7-score global symptom scale(GOSS)and functional digestive disorder quality of life scale(FDDQL)were used to evaluate the clinical symptoms and quality of life before and after treatment.The expression levels of serum gastrin(GAS),5-hydroxytryptamine(5-HT),and motilin(MLT)were detected by using the radioimmunoassay method.The clinical effective rates of the two groups after 3 months treatment were compared.Results After 3 months of treatment,the scores of GOSS and the levels of 5-HT in both groups decrease,while the scores of FDDQL,and the levels of GAS and MLT increase,with statistically significant differences(P<0.05).After 3 months of treatment,the scores of GOSS and the levels of 5-HT in the observation group are lower than those in the control group,while the scores of FDDQL,and the levels of GAS and MLT are higher than those in the control group,with statistically significant differences(P<0.05).After 3 months of treatment,the clinical effective rate of the observation group is 95.12%,which is higher than that of the control group(78.05%),with a statistically significant difference(P<0.05).Conclusions Clostridium butyricum capsule combined with itopride can effectively relieve the digestive tract symptoms of FD patients,improve the gastrointestinal peristalsis function and clinical efficacy,which is beneficial to improving the quality of life of FD patients.It has a certain value of clinical promotion.

关 键 词：酪酸梭菌活菌胶囊 伊托必利 功能性消化不良 胃肠激素 

分 类 号：R57[医药卫生—消化系统]