着丝粒蛋白家族对肝癌恶性生物学行为调节的研究进展  

Progress in regulation of centromere protein family on malignant biological behavior of hepatocellular carcinoma

作　　者：何坤 高孝锦 谢梦忆 李敬东[1,2] HE Kun;GAO Xiaojin;XIE Mengyi;LI Jingdong(Clinical Medical College of North Sichuan Medical College,Nanchong,Sichuan 637000,P.R.China;The First Department of Hepatobiliary Surgery,Affiliated Hospital of North Sichuan Medical College,Institute of Hepatobiliary,Pancreatic and Intestinal Diseases,North Sichuan Medical College,Nanchong,Sichuan 637000,P.R.China)

机构地区：[1]川北医学院临床医学院,四川南充637000 [2]川北医学院附属医院肝胆外一科、川北医学院肝胆胰肠疾病研究所,四川南充637000

出　　处：《中国普外基础与临床杂志》2024年第6期761-768,共8页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家卫生健康委医药卫生科技发展研究项目(项目编号:WA2021RW26)。

摘　　要：目的了解着丝粒蛋白(centromere proteins,CENPs)家族在肝癌中的临床价值和对肝癌恶性生物学行为的影响,为该领域相关研究提供参考。方法检索国内外数据库中近年来有关CENPs在肝癌中研究的相关文献并进行分析和综述。结果共总结了11种与肝癌密切相关的CENPs,它们在肝癌组织中存在差异表达并与预后相关,CENPs可通过多种机制调节肝癌的增殖、转移、凋亡、放化疗抵抗等多种恶性生物学行为,进而参与肝癌的发生发展,仍有部分CENPs在肝癌中的作用和机制尚不清楚。结论CENPs在肝癌的诊断、治疗和预后评价中发挥重要作用,它们参与了肝癌多种恶性生物学行为,有望成为肝癌潜在的治疗靶点,但其在肝癌中的作用和机制有待深入研究。Objective To understand the clinical value of centromere proteins(CENPs)in hepatocellular carcinoma and their influence on the malignant biological behavior of hepatocellular carcinoma,and to provide theoretical references for related research in this field.Method Domestic and international databases were searched for relevant literatures on the study of CENPs in hepatocellular carcinoma in recent years to be analyzed and reviewed.Results A total of 11 CENPs closely related to hepatocellular carcinoma had been summarized,which were differentially expressed in hepatocellular carcinoma and correlated with prognosis.CENPs might regulate various malignant biological behaviors such as hepatocellular carcinoma proliferation,metastasis,apoptosis,and resistance to radiotherapy and thus participate in the development of hepatocellular carcinoma via multiple mechanisms.The roles and mechanisms of some CENPs in hepatocellular carcinoma remained unclear.Conclusions CENPs play an essential role in the diagnosis,treatment,and prognosis of hepatocellular carcinoma.They are involved in multiple malignant biological behaviors of hepatocellular carcinoma and are expected to be potential therapeutic targets for hepatocellular carcinoma.However,their roles and mechanisms in hepatocellular carcinoma remain to be investigated.

关 键 词：着丝粒蛋白 肝癌 生物学标志物 恶性生物学行为 

分 类 号：R735.7[医药卫生—肿瘤]