盆腔肿瘤外照射放疗危及器官保护研究进展  

Advances in research on organ-at-risk protection in pelvic tumor external beam radiotherapy

作　　者：曾福斌 赵文娟 何洁[1,2] 陈迪 张火俊 ZENG Fubin;ZHAO Wenjuan;HE Jie;CHEN Di;ZHANG Huojun(Department of Radiation Therapy,The First Affiliated Hospital of Naval Medical University,Shanghai 200433,P.R.China;School of Health Sciences and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,P.R.China)

机构地区：[1]海军军医大学第一附属医院放疗科,上海200433 [2]上海理工大学健康科学与工程学院,上海200093

出　　处：《生物医学工程学杂志》2024年第3期627-634,共8页Journal of Biomedical Engineering

基　　金：国家自然科学基金面上项目(82272742);科技部国家重点研发计划(2022YFC2503701);上海卫生健康委员会领军人才计划(2022LJ019);上海市抗癌协会“雏鹰”计划(SACA-CY22A02);长海医院“固海”计划(GH145-33)

摘　　要：如何在摧毁肿瘤细胞的同时保护盆腔内的正常器官,是盆腔肿瘤放射治疗领域在临床和技术上面临的双重挑战。本文通过评述最新文献,聚焦于放疗定位、计划设计、实施等关键环节中的技术创新,包括:摆位固定技术、危及器官避让照射技术和非共面照射技术,以及器官移位保护和图像引导的自适应技术等,总结并讨论了盆腔肿瘤放疗中危及器官保护的研究进展。本文重点关注放疗定位、计划设计、实施各环节中危及器官保护的技术进展,旨在为盆腔肿瘤外照射放疗中危及器官保护的进一步研究奠定基础。The simultaneous objectives of destroying tumor cells while protecting normal pelvic organs present a dual clinical and technical challenge within the realm of pelvic tumor radiotherapy.This article reviews the latest literatures,focusing on technological innovations in key aspects of radiotherapy such as positioning,planning,and delivery.These include positioning fixation techniques,organ-at-risk avoidance irradiation,non-coplanar irradiation techniques,as well as organ displacement protection and image-guided adaptive techniques.It summarizes and discusses the research progress made in the protection of critical organs during pelvic tumor radiotherapy.The paper emphasizes technological advancements in the protection of critical organs throughout the processes of radiotherapy positioning,planning,and implementation,aiming to provide references for further research on the protection of critical organs in the external irradiation treatment of pelvic tumors.

关 键 词：盆腔肿瘤 放射治疗 外照射 危及器官保护 

分 类 号：R730.55[医药卫生—肿瘤]