Electrochemical Dearomative Spirocyclization of N-Acyl Sulfonamides in a Continuous-Flow Cell  

作　　者：Ting Liu Zhaojiang Shi Yaofeng Yuan Yuqi Lin Ke-Yin Ye 

机构地区：[1]Key Laboratory of Molecule Synthesis and Function Discovery(Fujian Province University),College of Chemistry,Fuzhou University Fuzhou,Fujian350108,China

出　　处：《Chinese Journal of Chemistry》2024年第9期980-984,共5页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.22171046);the Hundred-Talent Project of Fujian(No.50021113).

摘　　要：The development of efficient and sustainable methods to obtain spirocyclic compounds is of significance as these structures are widely found in pharmaceuticals and agrochemicals.Herein,we disclose an electrochemical dearomative spirocyclization of N-acyl sulfonamides in a continuous-flow cell.The reaction is simple and efficient without external catalysts or supporting electrolytes and could be applied in a decagram-scale synthesis.

关 键 词：Electrochemistry CONTINUOUS-FLOW DEAROMATIZATION SPIROCYCLIZATION SULFONAMIDES CYCLIZATION Methodology and reactions 

分 类 号：O64[理学—物理化学]