Long-term olfactory loss post-COVID-19:Pathobiology and potential therapeutic strategies  

作　　者：Sarah Kim John B.Finlay Tiffany Ko Bradley J.Goldstein 

机构地区：[1]Department of Head and Neck Surgery&Communication Sciences,Duke University,Durham,North Carolina,USA [2]Medical Scientist Training Program,Duke University,Durham,North Carolina,USA [3]Department of Neurobiology,Duke University,Durham,North Carolina,USA

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2024年第2期148-155,共8页世界耳鼻咽喉头颈外科杂志（英文）

摘　　要：An acute loss of smell emerged as a striking symptom present in roughly half of the people infected with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus in the early phases of the COVID-19 pandemic.In most COVID-19 patients,olfaction recovers over the course of a few weeks.However,a lasting partial or complete loss of smell,often associated with distorted olfactory perceptions termed parosmia,has emerged as a widespread problem impacting at least 5%-10%of those who experience anosmia due to COVID-19.Our inability to offer effective therapies to this hyposmic or anosmic population,comprising millions of patients,highlights an enormous unmet need for the medical system.Here,we summarize the current understanding of the pathobiology causing acute olfactory loss due to SARS-CoV-2 infection,focusing on how the virus interacts with the peripheral olfactory system,a major site of viral infection.We also explore the problem of long-COVID olfactory dysfunction,which may accompany other persistent systemic disorders collectively termed postacute sequelae of COVID-19.Specifically,we discuss an emerging model focused on unresolved immune cell activity driving ongoing dysfunction.Finally,we review current and future therapeutic approaches aimed at restoring olfactory function.

关 键 词：HYPOSMIA INFLAMMATION long-COVID parosmia 

分 类 号：R511[医药卫生—内科学]