精神分裂症患者脑结构纵向变化的研究进展  

Research progress on longitudinal changes of brain structure in patients with schizophrenia

作　　者：江启彤 薄奇静[1,2] 赵蕾[1,2] 李田[1,2] 陈真竹 王怡梦 王传跃 Jiang Qitong;Bo Qijing;Zhao Lei;Li Tian;Chen Zhenzhu;Wang Yimeng;Wang Chuanyue(The National Clinical Research Center for Mental Disorders,Beijing Key Laboratory of Mental Disorders,Beijing Institute for Brain Disorders Center of Schizophrenia,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京安定医院、国家精神心理疾病临床医学研究中心、精神疾病诊断与治疗北京市重点实验室北京脑重大疾病研究院精神分裂症研究所,北京100088 [2]首都医科大学人脑保护高精尖创新中心,北京100069

出　　处：《中华精神科杂志》2024年第6期383-389,共7页Chinese Journal of Psychiatry

基　　金：北京市医院管理中心临床医学发展专项(ZLRK202335)。

摘　　要：精神分裂症是一种病因复杂的慢性致残性疾病,其神经影像学异常已被大量研究所证实。但这些结构异常何时发生以及如何随时间进展尚不明确,其与抗精神病药治疗间的关系有待深入探索。对精神病临床高危人群、首次发病精神分裂症及慢性精神分裂症患者的脑结构进行纵向研究,并探索药物治疗对其的影响,有助于构建精神分裂症全病程脑结构改变轨迹,动态追踪患者的脑结构变化,明确药物因素对脑结构变化的效应,从而进一步探究精神分裂症的病理生理机制,发掘潜在生物学标志物,为精神分裂症的早期诊断、预后判断提供依据。本文就精神分裂症患者脑结构纵向变化的研究进展进行综述。Schizophrenia is a chronic disabling disease of unknown etiology.Its neuroimaging abnormalities have been confirmed by a large number of studies.However,when these structural abnormalities occur and how they develop over time are unclear.The relationship between structural abnormalities and antipsychotic treatment needs to be further explored.Longitudinal studies on the brain structure of clinical high risk for psychosis,first-episode schizophrenia and chronic schizophrenia,exploring the influence of drug therapy on them,are helpful to construct the trajectories of brain structure changes in the whole course of schizophrenia and dynamically track the brain structure changes,so as to further explore the pathophysiology of schizophrenia.This article reviews the longitudinal research progress of brain structure changes in patients with schizophrenia.

关 键 词：精神分裂症 磁共振成像 抗精神病药 

分 类 号：R749.3[医药卫生—神经病学与精神病学]