LncRNA调控反刍家畜脂质代谢的研究进展  

Research Progress on Regulation of lncRNA on Lipid Metabolism in Ruminants

作　　者：吴刚 倪萌萌 李世军 WU Gang;NI Mengmeng;LI Shijun(Key Laboratory of Animal Genetics,Breeding and Reproduction in the Plateau Mountainous Region,College of Animal Science,Guizhou University,Guizhou Guiyang 550025,China;Key Laboratory of Animal Genetics,Breeding and Reproduction in Guizhou,Guizhou Guiyang 550025,China)

机构地区：[1]贵州大学动物科学学院,高原山地动物遗传育种与繁殖教育部重点实验室,贵州贵阳550025 [2]贵州省动物遗传育种与繁殖重点实验室,贵州贵阳550025

出　　处：《中国畜牧杂志》2024年第6期7-14,共8页Chinese Journal of Animal Science

基　　金：贵州省科技计划项目(黔科合基础-ZK[2023]一般086);贵州大学引进人才科研项目(贵大人基合字[2021]3号)。

摘　　要：脂质代谢对机体的生长发育、繁殖等均有重要作用,反刍家畜的背膘厚、肌内脂肪含量和乳脂率等经济性状与脂质代谢密切相关。长链非编码RNA(lncRNA)是长度大于200核苷酸的非编码RNA,近年来研究发现lncRNA可以通过干扰基因的表达、调控酶活性、竞争靶位点等方式参与许多重要的机体代谢。在畜牧经济性状研究中,lncRNA可通过调控脂质代谢影响肌内脂肪的沉积及乳脂率,从而影响反刍家畜的肉质、乳质性状。本文对lncRNA调控反刍动物肉质性状与产乳性状的脂质代谢途径及相关研究进行综述,以期对反刍家畜经济性状的改善提供理论依据。The metabolism of lipids is crucial for growth,development,and reproduction.Many economic traits such as backfat thickness,intramuscular fat content and milk fat percentage of ruminant livestock are closely related to lipid metabolism.Long non-coding RNA(lncRNA)is a non-coding RNA with a length of more than 200 nucleotides.In recent years,it has been discovered that lncRNA can play a crucial role in body metabolism by interfering with gene expression,regulating enzyme activity,and competing for target sites.In the study of livestock economic traits,lncRNA can affect intramuscular fat deposition and milk fat percentage by regulating lipid metabolism,thus affecting meat and milk quality traits of ruminant livestock.This paper reviews the regulatory effects of lncRNA on beef and milk production,aiming to provide a theoretical basis for improving the economic traits of ruminants.

关 键 词：lncRNA 反刍家畜 脂质代谢 IMF 乳脂 

分 类 号：S813.1[农业科学—畜牧学]