全身免疫炎症指数在溃疡性结肠炎病情评估中的应用  

The Application of Systemic Immuno-inflammatory Index in the Assessment of Ulcerative Colitis

作　　者：吴南 王忠奇 鲁明月 李静 Wu Nan;Wang Zhongqi;Lu Mingyue;Li Jing(The First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000 China;Anshan Central Hospital,Anshan 114000 China)

机构地区：[1]锦州医科大学附属第一医院,辽宁锦州121000 [2]鞍山市中心医院,辽宁鞍山114000

出　　处：《锦州医科大学学报》2024年第3期42-48,共7页Journal of Jinzhou Medical University

基　　金：辽宁省民生科技计划项目,项目编号:2021JH2/10300042。

摘　　要：目的 探讨全身免疫炎症指数(systemic immune-inflammation index, SII)对溃疡性结肠炎(ulcerative colitis, UC)活动度及病变范围的评估价值。方法 选取2021年9月至2023年8月就诊于鞍山市中心医院的UC患者103例及同期的健康体检者80例。收集分析UC组、对照组的相关病例资料及血清学指标,比较这些指标在不同活动程度和病变范围之间的差异性。对血清学炎症指标与UC疾病活动度和病变范围进行相关性分析。采用ROC曲线评价各炎症指标对UC活动性和病变范围的诊断效能。结果 与对照组相比,UC组患者的SII明显增高(P<0.05)。进一步分析,在不同疾病活动度UC组中,SII水平差异具有统计学意义(P<0.05);随着UC患者病变范围的扩大,SII水平也会升高(P<0.05)。相关性分析表明,SII水平与UC患者的Mayo评分和病变范围均呈正相关(P<0.05)。ROC曲线结果显示,SII对于UC患者病情活动度及病变范围的评估作用优于其他免疫炎症指标(AUC分别为0.782和0.768,最佳截断值分别为512.143和677.99,灵敏度分别为72.40%和69.40%,特异度分别为81.30%和76.10%)。结论 UC患者的SII水平升高与疾病活动度和病变范围相关。此外,SII与CRP、PLR等血清学炎症指标相比,对UC的活动度和病变范围具有更高的预测价值。Objective To investigate the value of systemic immunoinflammatory index in evaluating the activity and lesion extent of ulcerative colitis.Methods A total of 103 UC patients admitted to Anshan Central Hospital from September 2021 to August 2023 and 80 healthy subjects during the same period were selected.The relevant clinical data and serological indicators of UC group and control group were collected and analyzed,and the differences of these indicators between different activity degrees and lesion ranges were compared.The correlation between serological inflammatory markers and UC disease activity and lesion range was analyzed.Receiver operating characteristic curve was used to evaluate the diagnostic efficacy of each inflammatory index on UC activity and lesion extent.Results Compared with control group,SII in UC group was significantly increased(P<0.05).Further analysis showed that there were statistically significant differences in SII levels among UC groups with different disease activity levels(P<0.05);with the expansion of the lesion range in UC patients,the level of SII also increased(P<0.05).Correlation analysis showed that SII level was positively correlated with Mayo score and lesion range in UC patients(P<0.05).ROC curve results showed that SII was better than other immunoinflammatory indicators in evaluating disease activity and lesion range in UC patients(AUC was 0.782 and 0.768,the best cutoff values were 512.143 and 677.99,and the sensitivity was 72.40%and 69.40%,respectively.The specificity was 81.30%and 76.10%,respectively).Conclusion The level of SII in UC patients is elevated and correlated with disease activity and lesion extent.In addition,SII has a higher predictive value for the activity and lesion extent of UC than other serological inflammatory indicators such as C-reactive protein(CRP)and Platelet-lymphocyte ratio(PLR).

关 键 词：溃疡性结肠炎 全身免疫炎症指数 疾病活动度 病变范围 

分 类 号：R574.1[医药卫生—消化系统]