The dual function of cGAS-STING signaling axis in liver diseases  

作　　者：Xiao-jao-yang Li jiao-rong Qu Yin-hao Zhang Run-ping Liu 

机构地区：[1]School of Life Sciences,Beijing University of Chinese Medicine,11 Bei San Huan Dong Lu,Beijing,100029,China [2]School of Chinese Materia Medica,Beijing University of Chinese Medicine,11 Bei San Huan Dong Lu,Beijing,100029,China

出　　处：《Acta Pharmacologica Sinica》2024年第6期1115-1129,共15页中国药理学报（英文版）

基　　金：supported by the Beijing Nova Program of Science&Technology(Grant No.Z211100002121167 to RPL);the Fundamental Research Funds for the Central Universities to XJYL;the Fundamental Research Funds for the Central Universities(Grant No.2023-JYB-XJSJJ009 to JRQ);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No.ZYYCXTD-C-202006 to XJYL);Beijing Municipal Science&Technology Commission(Grant No.7212174 to XL);National Natural Science Foundation of China(Grant No.82004045 and 82274186 to XJYL);National Key Research and Development Program on Modernization of Traditional Chinese Medicine(No.6132022YFC3502100 to XJYL);the National High-Level Talents Special Support Program to XJYL.

摘　　要：Numerous liver diseases,such as nonalcoholic fatty liver disease,hepatitis,hepatocellular carcinoma,and hepatic ischemia-reperfusion injury,have been increasingly prevalent,posing significant threats to global health.In recent decades,there has been increasing evidence linking the dysregulation of cyclic-GMP-AMP synthase(cGAS)-stimulator of interferon gene(STING)-related immune signaling to liver disorders.Both hyperactivation and deletion of STING can disrupt the immune microenvironment dysfunction,exacerbating liver disorders.Consequently,there has been a surge in research investigating medical agents or mediators targeting cGAS-STING signaling.Interestingly,therapeutic manipulation of the cGAS-STING pathway has yielded inconsistent and even contradictory effects on different liver diseases due to the distinct physiological characteristics of intrahepatic cells that express and respond to STING.In this review,we comprehensively summarize recent advancements in understanding the dual roles of the STING pathway,highlighting that the benefits of targeting STING signaling depend on the specific types of target cells and stages of liver injury.Additionally,we offer a novel perspective on the suitability of STING agonists and antagonists for clinical assessment.In conclusion,STING signaling remains a highly promising therapeutic target,and the development of STING pathway modulators holds great potential for the treatment of liver diseases.

关 键 词：STING chronic liver diseases immune response dual regulation STING agonists STING inhibitors 

分 类 号：R575[医药卫生—消化系统]